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Despite progress in the diagnosis and treatment of CRC, the rate of mortality is still high. Identifying the molecular mechanisms contributing to CRC development and progression creates opportunities to provide better management for CRC. 14\u20103\u20103 proteins are extremely conserved phosphoserine\/phosphothreonine\u2010binding proteins found in all eukaryotic cells. These proteins regulate a number of biological processes in the cells by binding to their client proteins. Thereby, they can contribute to the regulation of cell cycle progression, proliferation, invasion, and metastasis, highlighting their role in cancer development, progression, and treatment. The present article is aimed at reviewing the 14\u20103\u20103 proteins and their biological function, as well as their contribution to cancer regulation. In addition, it will collect previously performed studies investigating the role of 14\u20103\u20103 proteins in CRC pathogenesis, emphasizing their potential for diagnostic, prognostic, and therapeutic purposes, offering insights into novel intervention strategies and personalized medicine approaches for CRC.<\/jats:p>","DOI":"10.1155\/bmri\/1090181","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:01:40Z","timestamp":1781334100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Importance of 14\u20103\u20103 Proteins in Colorectal Cancer Regulation: Mechanisms of Function and Clinical 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