{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:16:28Z","timestamp":1783588588243,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":189,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005639","name":"Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare maternal serum CRIPTO\u20101 concentrations in pregnancies complicated by placenta accreta spectrum (PAS) with those complicated by placenta previa (PP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, cross\u2010sectional, comparative study at a tertiary center in S\u00e3o Paulo, Brazil (August 2022\u2013May 2025). Singleton pregnancies with ultrasound\u2010confirmed PP were included and classified as either PP without accreta or PAS (accreta\/increta\/percreta) according to standardized imaging criteria and, when applicable, surgical\/histopathological confirmation. Maternal venous blood was collected predelivery, and serum CRIPTO\u20101 concentrations were measured using ELISA (Human CRIPTO SimpleStep ELISA Kit, Abcam). Primary analyses used nonparametric tests for continuous variables and Fisher\u2032s exact test for categorical variables. The study was approved by the Research Ethics Committee of the University of S\u00e3o Paulo (CAAE 58202122.8.0000.0065; CAAE 55121422.3.0000.0068).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010three participants were analyzed (PP = 18; PAS = 25). Median serum CRIPTO\u20101 did not differ significantly between groups (PP: 0.013\u2009pg\/mL, IQR: 0.001\u20130.067 vs. PAS: 0.079\u2009pg\/mL, IQR: 0.005\u20130.360;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.156). PAS was associated with greater blood loss (median 2240 vs. 568\u2009mL;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), higher transfusion rate (88.0% vs. 16.7%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), more ICU admissions (68.0% vs. 16.7%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), longer ICU and hospital stays (both\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), and higher hysterectomy rates (84.0% vs. 5.6%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Predelivery serum CRIPTO\u20101 did not discriminate PAS from PP, possibly reflecting physiological variability at delivery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/2476601","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:48:45Z","timestamp":1783586925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Concentration of CRIPTO\u20101 in Pregnancies Complicated by Placenta Accreta Spectrum"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5990-9006","authenticated-orcid":false,"given":"Livia Alves","family":"Lopes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-8268","authenticated-orcid":false,"given":"Mario Macoto","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4178-4625","authenticated-orcid":false,"given":"Estela","family":"Bevilacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2384-4754","authenticated-orcid":false,"given":"Carolina Burgarelli","family":"Testa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0599-0739","authenticated-orcid":false,"given":"Mario Henrique Burlacchini","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-8069","authenticated-orcid":false,"given":"Rossana Pulcineli Vieira","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-2136","authenticated-orcid":false,"given":"F\u00e1bio Roberto","family":"Cabar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.05.067"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1709324"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.074"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.02037.x"},{"key":"e_1_2_11_5_2","first-page":"347","article-title":"The Occurrence and Pathology of Placenta Accreta","volume":"33","author":"Hertig A. 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