{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:46:44Z","timestamp":1791794804958,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":284,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Nigella sativa<\/jats:italic>\n                      seeds have been used for the treatment of ailments.\n                      <jats:italic>Lepidium sativum<\/jats:italic>\n                      is another spice used in the treatment of asthma, cough, and bleeding piles. Despite their significance, a comprehensive synthesis of their ethnobotanical uses in Ethiopia remains limited. Therefore, this study was designed to carry out an ethnobotanical investigation on\n                      <jats:italic>L. sativum<\/jats:italic>\n                      and\n                      <jats:italic>N. sativa<\/jats:italic>\n                      seeds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study was conducted in Debre Berhan, Chacha, and Sheno towns located in the North Shewa Zone of the Amhara Regional State, Ethiopia. Semistructured interviews were employed among 65 informants to obtain ethnobotanical data. Data were entered into EpiData Version 3.1, then exported to SPSS Version 26.0 for statistical analysis. Descriptive statistics, including frequencies and percentages, were used to summarize the data. Ethnobotanical indices, including informant consensus factor (ICF) and fidelity level (FL), were calculated using the standard formulas. Associations between categorical and patterns of medicinal seed use were assessed using the Pearson chi\u2010square test. Statistical significance was considered at\n                      <jats:italic>p<\/jats:italic>\n                      value of &lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 65 individuals participated in the study. The majority of the respondents (93.8%) reported having used these seeds. Among those, 84.6% used both seeds in combination. ICF values ranged from 0.000 to 0.933 across six disease categories. The highest was recorded for digestive problems (ICF = 0.967) and general health (ICF = 0.958), with 31 and 25 use\u2010reports, respectively. The ethnobotanical indices showed a significant preference for the combined use of\n                      <jats:italic>L. sativum<\/jats:italic>\n                      and\n                      <jats:italic>N. sativa<\/jats:italic>\n                      with a frequency of citation (FC) value of 55 and a use value (UV) of 0.846.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this study, people use\n                      <jats:italic>L. sativum<\/jats:italic>\n                      and\n                      <jats:italic>N. sativa<\/jats:italic>\n                      seeds mostly for digestive problems and general health conditions. Future studies should investigate the phytochemical composition, mechanisms of action, toxicological effects, and clinical relevance of commonly used preparations of\n                      <jats:italic>L. sativum<\/jats:italic>\n                      and\n                      <jats:italic>N. sativa.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/2989902","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:14:10Z","timestamp":1791792850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medicinal Use of\n                    <i>Lepidium sativum<\/i>\n                    and\n                    <i>Nigella sativa<\/i>\n                    Seeds in North Shewa Zone, Amhara and Oromia Regions, Ethiopia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1277-2986","authenticated-orcid":false,"given":"Daniel Molla","family":"Melese","sequence":"first","affiliation":[{"name":"Department of Biomedical Science Asrat Woldeyes Health Science Campus Debre Berhan University  Debre Berhan Ethiopia  dbu.edu.et"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wondyefraw","family":"Mekonen","sequence":"additional","affiliation":[{"name":"Department of Physiology College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia  aau.edu.et"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8098-9688","authenticated-orcid":false,"given":"Abebaye","family":"Aragaw","sequence":"additional","affiliation":[{"name":"Department of Physiology College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia  aau.edu.et"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-016-0262-7"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(98)00300-8"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/jfq\/6615903"},{"key":"e_1_2_14_4_2","first-page":"186","article-title":"Spices Production in Ethiopia: A Review","volume":"43","author":"Deribe H.","year":"2022","journal-title":"Agricultural Reviews"},{"key":"e_1_2_14_5_2","first-page":"967","article-title":"Cardio-Protective and Anti-Cancer Therapeutic Potential of Nigella sativa","volume":"17","author":"Shafiq H.","year":"2014","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2006.01417.x"},{"key":"e_1_2_14_7_2","first-page":"745","article-title":"Biochemical Effects of Nigella sativa L Seeds in Diabetic Rats","volume":"44","author":"Kaleem M.","year":"2006","journal-title":"Indian Journal of Experimental Biology"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01131.x"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13002-025-00753-9"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.52763\/PJSIR.BIOL.SCI.68.1.2025.8.23"},{"key":"e_1_2_14_11_2","first-page":"36","article-title":"A Brief Review on Bioactivities and Therapeutic Potentials of Garden Cress (Lepidium sativum L.)","volume":"13","author":"Shabbir F.","year":"2018","journal-title":"International Journal of Chemical and Biochemical Sciences"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.31783\/elsr.2023.91108113"},{"key":"e_1_2_14_13_2","first-page":"464","article-title":"Pharmacognostical and Physicochemical Standardization of Ethnopharmacologically Important Seeds of Lepidium sativum Linn. and Wrightia tinctoria R","volume":"2","author":"Bigoniya P.","year":"2011","journal-title":"Indian Journal of Natural Products and Resources"},{"key":"e_1_2_14_14_2","volume-title":"Indian Medicinal Plants","author":"Kirtikar K. R.","year":"1991"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.5897\/AJPS2016.1439"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00084"},{"key":"e_1_2_14_17_2","first-page":"544","article-title":"An Investigation on LD50 and Subacute Hepatic Toxicity of Nigella sativa Seed Extracts in Mice","volume":"60","author":"Vahdati-Mashhadian N.","year":"2005","journal-title":"Die Pharmazie-An International Journal of Pharmaceutical Sciences"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(98)00241-4"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6651922"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5961067"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-11-4"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-9-68"},{"key":"e_1_2_14_23_2","first-page":"1","article-title":"Ethnomedicinal Study of Nigella sativa","volume":"2","author":"Khan N.","year":"2019","journal-title":"Advances in Agricultural Technology & Plant"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.5897\/AJPS2013.1041"},{"key":"e_1_2_14_25_2","first-page":"83","article-title":"Ethnobotanical Study of Medicinal Plants in Selected Horro Gudurru Woredas, Western Ethiopia","volume":"5","author":"Birhanu T.","year":"2015","journal-title":"Journal of Biology, Agriculture and Healthcare"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-017-2482-3"},{"key":"e_1_2_14_27_2","first-page":"6","article-title":"Assessment of Indigenous Knowledge of Medicinal Plants in Central Zone of Tigray, Northern Ethiopia","volume":"4","author":"Yirga G.","year":"2010","journal-title":"African Journal of Plant Science"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2025.e02571"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.56557\/jobari\/2022\/v28i37770"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.55168\/ssr2809-6029.2025.8003"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/2989902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bmri\/2989902","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/2989902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:14:13Z","timestamp":1791792853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bmri\/2989902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/bmri\/2989902"],"URL":"https:\/\/doi.org\/10.1155\/bmri\/2989902","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2989902"}}