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The aim of this study is to evaluate the effect of two osteoplastic materials on the healing of a cranial vault experimental defect by computed tomography. Two material systems are analyzed in detail: (i) a sodium alginate\u2013based matrix modified with hydroxyapatite microparticles and zinc ions and (ii) a chitosan\u2010based matrix containing in situ\u2013formed brushite nanoparticles; both sample types were loaded with cholecalciferol (VitD3). A total of 36 rats aged 6 months showed that the alginate\u2010based biomaterial promotes complete healing of the parietal bone defect after 200 days, whereas healing with the chitosan\u2010based biomaterials at that time was not complete. The second objective was to determine the kinetics of VitD3 release from experimental biocomposites using high\u2010performance liquid chromatography. The kinetics of VitD3 release depends on the material\u2032s composition: The composite with chitosan prolongs the drug release to 48\u2009h without the so\u2010called \u201cburst release.\u201d In the case of the alginate composite, a \u201cburst release\u201d of vitamin D3 is observed during the first 4\u2009h. Both osteoplastic materials show the potential to optimize reparative osteogenesis in an experimental defect of the flat skull bone, although the regenerative potential of the alginate\u2010based biomaterial is higher.<\/jats:p>","DOI":"10.1155\/bmri\/3257416","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:50:34Z","timestamp":1776246634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Healing Potential of Alginate and Chitosan\u2010Based Biomaterials for Cranial Bone Defects in Experimental Model"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-5642","authenticated-orcid":false,"given":"Oleksii V.","family":"Korenkov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9350-5766","authenticated-orcid":false,"given":"Liudmyla B.","family":"Sukhodub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-9223","authenticated-orcid":false,"given":"Mariia O.","family":"Kumeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9876-2509","authenticated-orcid":false,"given":"Leonid F.","family":"Sukhodub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt504"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2017.0230"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.03.022"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112993"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172327"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198701000-00041"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(97)80804-1"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885328207078075"},{"key":"e_1_2_10_9_2","first-page":"1669","article-title":"Radiographical and Clinical Evaluation of Critical Size Defects in Rabbit Calvaria Filled With Allograft and Autograft: A Pilot Study","volume":"7","author":"Gonzalo V.","year":"2014","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.202116"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202504467"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering12090915"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123752"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081129"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2016.0211"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000131016.12754.30"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181843609"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2020.1742291"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.112770"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-022-02419-1"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.03.016"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.22455"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-016-0072-2"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110991"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-016-0056-0"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2023.02.002"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.10.009"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.113"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2024.152290"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33868"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2022.103696"},{"key":"e_1_2_10_32_2","volume-title":"Calcium Phosphate Biomaterials: A Textbook","author":"Zyman Z. 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