{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:28:11Z","timestamp":1772987291335,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":345,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["300724\/2022-9"],"award-info":[{"award-number":["300724\/2022-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/20252-8"],"award-info":[{"award-number":["2018\/20252-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/01280-3"],"award-info":[{"award-number":["2021\/01280-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Oral mucositis affects up to 80% of patients undergoing bone marrow transplantation, causing painful ulcers, increased infection risk, and impaired quality of life. Current treatments are mainly palliative, highlighting the need for new therapeutic options.\n                      <jats:italic>Arrabidaea chica<\/jats:italic>\n                      Verlot extract has shown wound healing potential through antioxidant activity and collagen synthesis promotion in vitro and significant wound area reduction in vivo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The objective of the study is to evaluate the wound healing potential of a mucoadhesive gel containing 2.5%\n                      <jats:italic>A. chica<\/jats:italic>\n                      extract for treating oral mucositis in oncohematological patients undergoing bone marrow transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a randomized, controlled, open\u2010label, parallel\u2010group clinical trial conducted at HC\/UNICAMP from October 2022 to November 2024. Forty\u2010four patients were randomized to the intervention group (mucoadhesive\n                      <jats:italic>A. chica<\/jats:italic>\n                      gel,\n                      <jats:italic>n<\/jats:italic>\n                      = 22) or control group (low\u2010intensity laser therapy,\n                      <jats:italic>n<\/jats:italic>\n                      = 22). The primary outcome was the time to healing of oral mucositis. Statistical analysis compared mean healing times between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty participants in the intervention group and 18 in the control group completed the study. Mean healing time was 5.2 \u00b1 1.5 days for the intervention group and 11.2 \u00b1 6.5 days for the control group, representing a 2.2\u2010fold faster healing with\n                      <jats:italic>A. chica<\/jats:italic>\n                      gel. Some intervention participants reported a mild burning sensation, without affecting treatment adherence or efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The mucoadhesive gel containing\n                      <jats:italic>A. chica<\/jats:italic>\n                      extract proved to be a safe and effective therapeutic option for treating oral mucositis in patients undergoing bone marrow transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ReBEC number: RBR\u20105\u00d74397<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/3700170","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:37:31Z","timestamp":1765535851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Healing Oral Mucositis With\n                    <i>Arrabidaea chica<\/i>\n                    Verlot Mucoadhesive Gel in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Controlled Clinical Trial"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1510-5684","authenticated-orcid":false,"given":"N\u00fabia","family":"de C\u00e1ssia Almeida Queiroz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-3199","authenticated-orcid":false,"given":"Ilza Maria","family":"de Oliveira Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio Jos\u00e9 Machado","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-1313","authenticated-orcid":false,"given":"Afonso Celso","family":"Vigorito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elida Adriana","family":"de Castro Aranha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2645-1937","authenticated-orcid":false,"given":"Andressa Gomes","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6901-6815","authenticated-orcid":false,"given":"Jo\u00e3o Ernesto","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5478-0977","authenticated-orcid":false,"given":"Mary Ann","family":"Foglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_11_1_2","unstructured":"World Health Organization 2025 https:\/\/www.who.int\/health-topics\/cancer#tab=tab_1."},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21704"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33100"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23714"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55020025"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-021-03400-4"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30010074"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2012.761947"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.47749\/T\/UNICAMP.2014.927881"},{"key":"e_1_2_11_11_2","volume-title":"Avalia\u00e7\u00e3o da estabilidade do Extrato seco e formula\u00e7\u00f5es de bases semi s\u00f3lidas contend Arrabidaea chica Verlot, para uso em cicatriza\u00e7\u00e3o","author":"de Oliveira Sousa I. 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