{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:51:02Z","timestamp":1773661862755,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":74,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prostate\u2010specific antigen (PSA) is widely used for prostate cancer screening, but its limited specificity in the diagnostic \u201cgrey zone\u201d (4\u201310\u2009ng\/mL) results in unnecessary biopsies. This study evaluated urinary epithelial cell adhesion molecule (EpCAM), normalised to urinary creatinine, as a noninvasive biomarker for identifying clinically significant prostate cancer (csPCa) in men with equivocal PSA levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 286 men with PSA levels of 4\u201310\u2009ng\/mL scheduled for prostate biopsy. Histopathological outcomes were classified using ISUP Grade Groups. Urinary EpCAM was quantified by ELISA, and diagnostic performance for csPCa was assessed using nonparametric analyses, ROC curves and logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Urinary EpCAM\/Cr levels increased significantly across diagnostic categories and were highest in men with csPCa (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). EpCAM\/Cr showed strong discrimination for csPCa (AUC = 0.816), outperforming serum PSA and PSA density. In multivariable analysis, EpCAM\/Cr (aOR = 1.07; 95% CI: 1.02\u20131.14;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009) and PSA density (aOR = 1.81; 95% CI: 1.20\u20133.18;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013) were independent predictors of csPCa, and EpCAM\/Cr correlated positively with tumour aggressiveness (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = 0.609;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Urinary EpCAM\/Cr shows promise as a noninvasive biomarker for detecting csPCa in men with PSA levels in the diagnostic grey zone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/3839816","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:53:13Z","timestamp":1773658393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary Epithelial Cell Adhesion Molecule (EpCAM) as a Noninvasive Biomarker for Detecting Clinically Significant Prostate Cancer in Men With Equivocal PSA Levels"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-6575","authenticated-orcid":false,"given":"Bismark","family":"Opoku Mensah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0252-3190","authenticated-orcid":false,"given":"Linda Ahenkorah","family":"Fondjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9925-1015","authenticated-orcid":false,"given":"Paul","family":"Nsiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-9894","authenticated-orcid":false,"given":"Emma","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.31557\/apjcb.2025.10.2.393-400"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.210076"},{"key":"e_1_2_9_3_2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/00000421-200112000-00017","article-title":"Combined Use of Prostate-Specific Antigen Derivatives Decreases the Number of Unnecessary Biopsies to Detect Prostate Cancer","volume":"24","author":"\u00d6zen H.","year":"2001","journal-title":"American journal of clinical oncology"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2024.106588"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17132137"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/diseases13060167"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.15698\/cst2019.06.188"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04390-2"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09898-3"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20120128"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2011.04.002"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603494"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-4-S1-S2"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyac109"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1996.tb03538.x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"crossref","DOI":"10.21105\/joss.03118","article-title":"Presize: An R-Package for Precision-Based Sample Size Calculation in Clinical Research","volume":"6","author":"Haynes A. 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