{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:55:50Z","timestamp":1769918150252,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["27218"],"award-info":[{"award-number":["27218"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Liver cirrhosis is one of the most common causes of death for pediatric patients with cholestasis. Because microRNA (miRNA) plays a part in the pathogenesis of the disease, comparing the changes in miRNA expression in cholestatic patients with liver cirrhosis could be helpful for therapeutic or prognostic purposes. miRNA levels in cirrhotic pediatric patients with progressive familial intrahepatic cholestasis (PFIC) and biliary atresia (BA) were studied in this research to comprehend the molecular distinctions and the significance of miRNA regulation in fibrosis and liver cirrhosis. Blood samples were collected from 43 PFIC patients and 84 BA patients, all of whom were confirmed to have liver cirrhosis. The in\u2010house SYBR Green RT\u2010qPCR techniques were established to assess the variations in the expressions of 12 miRNAs. Utilizing bioinformatics tools, the gene targets of the studied miRNAs were examined. Patients\u2032 expression of 12 miRNAs was higher than that of the healthy group. However, there was a notable distinction between the miRNAs in PFIC and BA. The levels of miR\u201034, miR\u2010155, miR\u2010199, miR\u2010200b, and miR\u2010222 were significantly higher in BA than in PFIC. PFIC showed a significantly higher level of miR\u2010223 than BA. The predictive importance of distinct miRNAs in both diseases was revealed by the AUC values. In BA, miR\u2010222 was associated with both liver transplantation and the PELD score. Death was correlated with miR\u201021, miR\u2010155, miR\u2010199, and miR\u2010200 in BA and miR\u201034 in PFIC. The analysis showed the significance of the connection between miRNA expression and PI3K\/Akt and TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    signaling in pediatric liver cirrhosis. Future investigations can evaluate the significance of the studied miRNAs as novel therapeutic targets and diagnostic options.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/4087823","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T14:48:48Z","timestamp":1769870928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of miRNA Expression in Pediatric Cirrhosis Caused by BA and PFIC"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3312-9222","authenticated-orcid":false,"given":"Fatemeh","family":"Khosravi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-8621","authenticated-orcid":false,"given":"Ramin","family":"Yaghobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-3612","authenticated-orcid":false,"given":"Afsoon","family":"Afshari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9534-4014","authenticated-orcid":false,"given":"Nasrin","family":"Motazedian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4867-5686","authenticated-orcid":false,"given":"Bita","family":"Geramizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-4677","authenticated-orcid":false,"given":"Tayebeh","family":"Kazemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-0110","authenticated-orcid":false,"given":"Seyed Mohsen","family":"Dehghani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.4103\/sjg.sjg_112_21"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000015593"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00533-x"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.617261"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i47.7470"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i3.392"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/428638"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i23.7312"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/acmi.0.000127"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137167"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2023.35"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2020.66.5.1"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2021.0175"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01596-2"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24194"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-019-4227-y"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.09.009"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30288"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318244148b"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0161-7"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.09.018"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.02.065"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000000573"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.21037\/tp-23-424"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300717"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.181"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2022041823"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6962"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.07.012"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169380"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111002"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2846"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14573"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158657"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.895242"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1515\/med-2023-0879"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-021-05009-7"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0752-1"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2022.08.013"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.730176"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.01.003"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.110979"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.59876"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.781815"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12696"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S137209.eCollection"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1242009"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11113012"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2017.03.003"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/4087823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bmri\/4087823","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/4087823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T14:48:49Z","timestamp":1769870929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bmri\/4087823"}},"subtitle":[],"editor":[{"given":"Baisakhi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/bmri\/4087823"],"URL":"https:\/\/doi.org\/10.1155\/bmri\/4087823","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4087823"}}