{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:18:41Z","timestamp":1786115921874,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":216,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Prolonged exposure to UVB radiation accelerates skin photoaging by inducing DNA damage, promoting collagen degradation, and triggering cellular senescence. There is a growing interest in identifying effective natural interventions to prevent or mitigate these adverse effects. This study investigated the protective role and underlying mechanisms of donkey milk\u2010derived exosomes (DM\u2010Exos) against UVB\u2010induced skin aging using both in vitro skin cell models and in vivo mouse models. The results demonstrated that DM\u2010Exos significantly reduced UVB\u2010induced cellular senescence, as evidenced by decreased\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010galactosidase activity and downregulation of senescence\u2010associated genes. DM\u2010Exos also attenuated intracellular ROS production and reduced DNA damage markers (\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010H2AX and 8\u2010OHdG) both in vitro and in vivo. Transcriptomic analysis further revealed that DM\u2010Exos mitigated UVB\u2010induced alterations in pathways related to cellular senescence, DNA damage, cell proliferation, and response to UV radiation, which were corroborated by qPCR validation of key aging\u2010related genes. These findings underscore the potential of DM\u2010Exos as a promising natural agent for protecting against UVB\u2010induced skin aging and maintaining overall skin health.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/4214259","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T05:49:46Z","timestamp":1785995386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of Donkey Milk\u2010Derived Exosomes Against UVB\u2010Induced Skin Photoaging via Regulation of DNA Damage and Aging\u2010Related 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