{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:12:58Z","timestamp":1775736778127,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":98,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      This study is aimed at evaluating the relationship between preoperative\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography (\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET\/CT) findings and histopathological necrosis rates following chemotherapy in patients diagnosed with osteosarcoma (OST) and Ewing sarcoma (EWS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients diagnosed with OST and EWS between 2017 and 2023 were retrospectively analyzed. Data recorded included preoperative\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET\/CT findings, demographic characteristics, histopathological diagnosis, maximum standardized uptake value at diagnosis (SUVmax1), maximum standardized uptake value after neoadjuvant chemotherapy (SUVmax2), the SUVmax change ratio (SUVmax2\/SUVmax1 = SCR), and the percentage of tumor necrosis in resected specimens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 49 patients (33 OST and 16 EWS) were included, consisting of 22 females (44.9%) and 27 males (55.1%) with a median age of 12 years (range: 4\u201320). Median SUVmax1, SUVmax2, and SCR values were 6.8 (0\u201322.5), 2.5 (0\u20139.42), and 0.38 (0\u20131.44), respectively. The median tumor necrosis percentage was 20% (range: 0\u2013100). Stratification according to SUVmax2 (&lt;\u20092.5 vs. \u2265\u20092.5) revealed no significant difference in necrosis percentage (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.234). No significant correlation was observed between SCR and necrosis percentage (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.102). However, a significant inverse correlation was found between SUVmax2 and necrosis percentage in the overall cohort (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.040,\n                      <jats:italic>r<\/jats:italic>\n                      = \u20130.295), which was more pronounced in OST patients (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014,\n                      <jats:italic>r<\/jats:italic>\n                      = \u20130.426).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET\/CT is a valuable imaging modality for predicting histopathological response in solid tumors. Consistent with adult studies, our findings demonstrate that post\u2010NACT FDG uptake is inversely correlated with tumor necrosis percentage, particularly in pediatric OST patients. These results highlight the potential of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET\/CT as a noninvasive prognostic tool to assist in early identification of poor responders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/4420962","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:32:16Z","timestamp":1775734336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SUVmax on\n                    <sup>18<\/sup>\n                    F\u2010FDG PET\/CT and Histopathological Necrosis in Osteosarcoma and Ewing Sarcoma"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-303X","authenticated-orcid":false,"given":"\u015eule \u00c7al\u0131\u015fkan","family":"Kam\u0131\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-4986","authenticated-orcid":false,"given":"Metin","family":"\u00c7il","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6517-6953","authenticated-orcid":false,"given":"Emel Ko\u00e7yi\u011fit","family":"Deveci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-4487","authenticated-orcid":false,"given":"Zeynel Abidin","family":"Ta\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-4501","authenticated-orcid":false,"given":"Beg\u00fcl","family":"Ya\u011fc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31816e22f3"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24121"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.776"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.5505\/jkartaltr.2011.82787"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24320"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21219"},{"key":"e_1_2_13_7_2","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","year":"2013"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.5835\/jecm.omu.27.02.007"},{"key":"e_1_2_13_9_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/1097-0142(19950101)75:1+<203::AID-CNCR2820751308>3.0.CO;2-V","article-title":"Bone Cancers","volume":"75","author":"Dorfman H. 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