{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:17:19Z","timestamp":1783667839263,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":189,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Mussaenda pubescens<\/jats:italic>\n                      (Rubiaceae) is a medicinal plant, traditionally utilized for gastrointestinal, febrile, and reproductive ailments. This study was aimed at analyzing the antioxidant capacity and antihyperlipidemic efficacy of the methanolic extract of\n                      <jats:italic>M. pubescens<\/jats:italic>\n                      in a high\u2010cholesterol diet\u2010induced hyperlipidemic mouse model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010five Swiss albino mice were randomly subdivided into five groups of five mice each: normal control, disease control, atorvastatin (20\u2009mg\/kg), 200\u2009mg\/kg of the extract, and 400\u2009mg\/kg of the extract. Hyperlipidemia was achieved by feeding a high\u2010fat diet for 28 days before the oral treatment was given for 12 consecutive days. The serum lipid profile and DPPH radical scavenging activity were then analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The extract improved the lipid abnormalities when compared with untreated hyperlipidemic mice (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). At 200\u2009mg\/kg, LDL\u2010C decreased to 11.25 \u00b1 1.05\u2009mg\/dL, whereas the 400\u2009mg\/kg dose reduced TG and VLDL\u2010C to 140.50 \u00b1 6.50 and 28.10 \u00b1 1.30\u2009mg\/dL, respectively. Atorvastatin demonstrated greater lipid normalization. The antioxidant activity was also shown by the extract with a DPPH assay, with an IC\n                      <jats:sub>50<\/jats:sub>\n                      value of 235.64\u2009\n                      <jats:italic>\u03bc<\/jats:italic>\n                      g\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The methanolic extract of\n                      <jats:italic>M. pubescens<\/jats:italic>\n                      exhibits potent antihyperlipidemic and antioxidant activities, validating its potential as a promising phytotherapeutic candidate for the management of hyperlipidemia and oxidative stress\u2013associated metabolic disorders. Further in\u2010depth phytochemical profiling and mechanistic studies are required for better evaluation of this extract.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/4490125","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:52:56Z","timestamp":1783666376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of\n                    <i>Mussaenda pubescens<\/i>\n                    Leaf Extracts Against Oxidative Stress and Dyslipidemia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1363-0533","authenticated-orcid":false,"given":"Md. 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