{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:01Z","timestamp":1787017801409,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":137,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006523","name":"University of Dhaka","doi-asserted-by":"publisher","award":["Reg\/Ad-3\/47852"],"award-info":[{"award-number":["Reg\/Ad-3\/47852"]}],"id":[{"id":"10.13039\/501100006523","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Ceriops decandra<\/jats:italic>\n                    (Griff.) Ding Hou, locally known as \u201cGoran\u201d in Bangladesh, is a recognized mangrove plant of the Sundarbans. Coastal communities living in tidal areas traditionally use this plant for treating various ailments. While numerous biological activities of this plant have been reported, its leaves of Bangladeshi origin have not been phytochemically characterized in detail. Phytochemical analysis led to the isolation and identification of five compounds, namely lupeol (\n                    <jats:bold>1<\/jats:bold>\n                    ), 3\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010\n                    <jats:italic>E<\/jats:italic>\n                    \u2010coumaroyllupeol (\n                    <jats:bold>2<\/jats:bold>\n                    ), betulin (\n                    <jats:bold>3<\/jats:bold>\n                    ), 3\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010hydroxylupenal (\n                    <jats:bold>4<\/jats:bold>\n                    ), and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sitosterol (\n                    <jats:bold>5<\/jats:bold>\n                    ).\n                    <jats:sup>1<\/jats:sup>\n                    H and\n                    <jats:sup>13<\/jats:sup>\n                    C NMR spectroscopic analyses and comparison of spectral data with published literature were performed to identify these compounds. Compound\n                    <jats:bold>4<\/jats:bold>\n                    is reported here for the first time from\n                    <jats:italic>C. decandra<\/jats:italic>\n                    , whereas Compounds\n                    <jats:bold>1\u20133<\/jats:bold>\n                    are reported for the first time from the leaves of Bangladeshi\u2010origin\n                    <jats:italic>C. decandra<\/jats:italic>\n                    . The in vivo assays were undertaken to support the plant\u2032s previously recognized analgesic and anti\u2010inflammatory relevance and to explore whether the newly characterized constituents may contribute to these effects. The crude methanolic leaf extract of\n                    <jats:italic>C. decandra<\/jats:italic>\n                    at the dose of 400\u2009mg\/kg body weight showed potent central and peripheral analgesic effects in acetic acid\u2013induced writhing, formalin\u2010induced licking, hot plate, tail immersion, and tail clip test in mice. The extract at 200\u2009mg\/kg also produced significant anti\u2010inflammatory activity in the carrageenan\u2010induced paw edema model, with peak inhibition of 29.81% at 3\u2009h postcarrageenan. Molecular docking with mu, COX\u20101, and COX\u20102 receptors revealed that Compounds\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    may have stronger analgesic potential than diclofenac sodium. The isolated compounds showed favorable absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties for drug development. In addition, Prediction of Activity Spectra for Substances (PASS) analysis indicated high predicted anticancer potential for the isolated compounds, warranting future investigation.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/4730586","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:41:45Z","timestamp":1779093705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolation of 3\n                    <i>\u03b2<\/i>\n                    \u2010Hydroxylupenal From\n                    <i>Ceriops decandra<\/i>\n                    Leaves and Evaluation of In Vivo Analgesic and Anti\u2010Inflammatory Effects Supported by Molecular Docking"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3006-6206","authenticated-orcid":false,"given":"Asef","family":"Raj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-8500","authenticated-orcid":false,"given":"Sania","family":"Ashrafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-977X","authenticated-orcid":false,"given":"Md. Sakhawat","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7955-7498","authenticated-orcid":false,"given":"Md. Saiful","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Abdullah","family":"Al-Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-5060","authenticated-orcid":false,"given":"Abu Bin","family":"Ihsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7038-3399","authenticated-orcid":false,"given":"Md. 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