{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:02:21Z","timestamp":1783630941920,"version":"3.55.0"},"reference-count":228,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Acute myocardial infarction is one of the leading causes of death in the world. Owing to the limited regenerative capacity of the heart, the development of therapeutic devices using cell therapy and tissue engineering has gained importance. Preclinical validation of these devices can provide evidence of their safety and efficacy in implantation in infarcted myocardium. In view of the growing number of proposed devices, it is necessary to establish an appropriate experimental protocol that mimics the clinical scenario. This review is aimed at describing the strategies used for the preclinical validation of an artificial myocardium, based on the purpose of the therapy and the experimental design. Overall, the development of cardiac devices has focused on in vitro or in situ strategies for cell delivery to the infarcted tissue and proper cell proliferation and differentiation. Efforts have also been made to search for new cell sources, blood vessel formation, development of an anti\u2010inflammatory phenotype, and electromechanical coupling of resident and implanted cardiomyocytes. Based on the published evidence, a seven\u2010stage process for the preclinical validation of cardiac regenerative therapy is proposed.<\/jats:p>","DOI":"10.1155\/bmri\/5247814","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:07:01Z","timestamp":1774436821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Key Steps in Murine Cardiac Engineering Validation: How Does It Affect the Efficiency of Cardiac Devices?"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6112-3851","authenticated-orcid":false,"given":"Nancy G.","family":"Viveros-Moreno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6072-5496","authenticated-orcid":false,"given":"X. Fernanda","family":"Rodriguez-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-3165","authenticated-orcid":false,"given":"Mario","family":"Garcia-Lorenzana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-8148","authenticated-orcid":false,"given":"Marcela","family":"Salazar-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8314-8996","authenticated-orcid":false,"given":"Laura","family":"Villavicencio-Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-9127","authenticated-orcid":false,"given":"Nohra E.","family":"Beltran-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9349"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073482"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-021-00140-4"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.01.85"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00292"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-019-0185-0"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072359"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111539"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.01.027"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b01886"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18-0120"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-018-0845-z"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00335.2017"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002667"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.23663.2"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.03.023"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0152.2653"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.019"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.02.012"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13165"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.121.058655"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121028"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15870-z"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.11.034"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42247-023-00534-8"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03750-6"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.32637"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.03.003"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.10.010"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.04.022"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100171"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.10.058"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ac94f9"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.03.052"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301581"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.03.015"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.135224"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.03.017"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ac8dc9"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.07.007"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.026"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900065"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bprint.2023.e00263"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020205"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304627"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2023.06.005"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.05.015"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303033"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.06.001"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.12"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.08.012"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122088"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00942"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b13571"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.2568"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125139"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2023.03.001"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/bit.26345"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00471.2017"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.02.013"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1080\/1061186x.2018.1531417"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10471"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00331.2021"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.122581"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c02956"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201800248"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104711"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b00760"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0194"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.112979"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202959"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.02.020"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-021-00154-y"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.08.031"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ac199a"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2016-0079"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.01.002"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.12.004"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.754254"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/stmcls\/sxab016"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04628-5"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1784"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-018-0543-x"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b06761"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.01.021"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.25504"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c08890"},{"key":"e_1_2_10_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2022.102616"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121231"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2023.2252921"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.38876"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302940"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20746"},{"key":"e_1_2_10_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200990"},{"key":"e_1_2_10_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202205062"},{"key":"e_1_2_10_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122364"},{"key":"e_1_2_10_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.03.035"},{"key":"e_1_2_10_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175238"},{"key":"e_1_2_10_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.10.033"},{"key":"e_1_2_10_100_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.63481"},{"key":"e_1_2_10_101_2","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.1013910"},{"key":"e_1_2_10_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120673"},{"key":"e_1_2_10_103_2","doi-asserted-by":"publisher","DOI":"10.1039\/c9tb01971e"},{"key":"e_1_2_10_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.127423"},{"key":"e_1_2_10_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep29601"},{"key":"e_1_2_10_106_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b20158"},{"key":"e_1_2_10_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.065"},{"key":"e_1_2_10_108_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020525"},{"key":"e_1_2_10_109_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168957"},{"key":"e_1_2_10_110_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13237319"},{"key":"e_1_2_10_111_2","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1196"},{"key":"e_1_2_10_112_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ac5574"},{"key":"e_1_2_10_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.03.038"},{"key":"e_1_2_10_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.04.021"},{"key":"e_1_2_10_115_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35993"},{"key":"e_1_2_10_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110296"},{"key":"e_1_2_10_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.08.017"},{"key":"e_1_2_10_118_2","doi-asserted-by":"publisher","DOI":"10.3791\/59591"},{"key":"e_1_2_10_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.03.003"},{"key":"e_1_2_10_120_2","doi-asserted-by":"publisher","DOI":"10.3791\/59958"},{"key":"e_1_2_10_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.10.026"},{"key":"e_1_2_10_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2017.12.006"},{"key":"e_1_2_10_123_2","doi-asserted-by":"publisher","DOI":"10.5935\/1678-9741.20140075"},{"key":"e_1_2_10_124_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3mb70222g"},{"key":"e_1_2_10_125_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575"},{"key":"e_1_2_10_126_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-019-3154-z"},{"key":"e_1_2_10_127_2","first-page":"8786","article-title":"Acute Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury: A Comparison","volume":"8","author":"Hashmi S.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2010.09.007"},{"key":"e_1_2_10_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.02.030"},{"key":"e_1_2_10_130_2","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202100942"},{"key":"e_1_2_10_131_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-019-01187-3"},{"key":"e_1_2_10_132_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.2959"},{"key":"e_1_2_10_133_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-020-00189-0"},{"key":"e_1_2_10_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.047"},{"key":"e_1_2_10_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105060"},{"key":"e_1_2_10_136_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv259"},{"key":"e_1_2_10_137_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204509"},{"key":"e_1_2_10_138_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202005038"},{"key":"e_1_2_10_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.01.005"},{"key":"e_1_2_10_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.12.025"},{"key":"e_1_2_10_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.05.005"},{"key":"e_1_2_10_142_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat9683"},{"key":"e_1_2_10_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.135976"},{"key":"e_1_2_10_144_2","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2018-0024"},{"key":"e_1_2_10_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.02.009"},{"key":"e_1_2_10_146_2","doi-asserted-by":"publisher","DOI":"10.1039\/c9bm00101h"},{"key":"e_1_2_10_147_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.2954"},{"key":"e_1_2_10_148_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.110"},{"key":"e_1_2_10_149_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-013-0528-2"},{"key":"e_1_2_10_150_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11091-2"},{"key":"e_1_2_10_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119513"},{"key":"e_1_2_10_152_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17742-z"},{"key":"e_1_2_10_153_2","doi-asserted-by":"publisher","DOI":"10.1113\/jp275548"},{"key":"e_1_2_10_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.02.022"},{"key":"e_1_2_10_155_2","doi-asserted-by":"publisher","DOI":"10.1097\/fjc.0000000000000760"},{"key":"e_1_2_10_156_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00245"},{"key":"e_1_2_10_157_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0211"},{"key":"e_1_2_10_158_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b00221"},{"key":"e_1_2_10_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.02.024"},{"key":"e_1_2_10_160_2","doi-asserted-by":"publisher","DOI":"10.1097\/prs.0000000000001193"},{"key":"e_1_2_10_161_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12942"},{"key":"e_1_2_10_162_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131446"},{"key":"e_1_2_10_163_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.117.305990"},{"key":"e_1_2_10_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109296"},{"key":"e_1_2_10_165_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy067"},{"key":"e_1_2_10_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.07.035"},{"key":"e_1_2_10_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.06.038"},{"key":"e_1_2_10_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.038"},{"key":"e_1_2_10_169_2","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.oa.11.01876"},{"key":"e_1_2_10_170_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2020.111789"},{"key":"e_1_2_10_171_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234087"},{"key":"e_1_2_10_172_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40883-023-00311-3"},{"key":"e_1_2_10_173_2","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1943060"},{"key":"e_1_2_10_174_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-023-04446-5"},{"key":"e_1_2_10_175_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03255-1"},{"key":"e_1_2_10_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2022.11.006"},{"key":"e_1_2_10_177_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-022-03612-1"},{"key":"e_1_2_10_178_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301186"},{"key":"e_1_2_10_179_2","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v15.i8.821"},{"key":"e_1_2_10_180_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112936"},{"key":"e_1_2_10_181_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEC.2009.0362"},{"key":"e_1_2_10_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.06.001"},{"key":"e_1_2_10_183_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b08659"},{"key":"e_1_2_10_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.09.013"},{"key":"e_1_2_10_185_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.010"},{"key":"e_1_2_10_186_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202110179"},{"key":"e_1_2_10_187_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2019.0340"},{"key":"e_1_2_10_188_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.109794"},{"key":"e_1_2_10_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.109941"},{"key":"e_1_2_10_190_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133511"},{"key":"e_1_2_10_191_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.08.019"},{"key":"e_1_2_10_192_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.07.011"},{"key":"e_1_2_10_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121849"},{"key":"e_1_2_10_194_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz066"},{"key":"e_1_2_10_195_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.117.006949"},{"key":"e_1_2_10_196_2","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-2501087\/v1"},{"key":"e_1_2_10_197_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66327-9"},{"key":"e_1_2_10_198_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-022-10468-z"},{"key":"e_1_2_10_199_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0259"},{"key":"e_1_2_10_200_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00827-8"},{"key":"e_1_2_10_201_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2022.110319"},{"key":"e_1_2_10_202_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154974"},{"key":"e_1_2_10_203_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe0726"},{"key":"e_1_2_10_204_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2021.151699"},{"key":"e_1_2_10_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.10.013"},{"key":"e_1_2_10_206_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.06.009"},{"key":"e_1_2_10_207_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121171"},{"key":"e_1_2_10_208_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.158"},{"key":"e_1_2_10_209_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-021-06611-w"},{"key":"e_1_2_10_210_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100415"},{"key":"e_1_2_10_211_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b17907"},{"key":"e_1_2_10_212_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.12.062"},{"key":"e_1_2_10_213_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2022.03.005"},{"key":"e_1_2_10_214_2","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18-0244"},{"key":"e_1_2_10_215_2","doi-asserted-by":"publisher","DOI":"10.3791\/55353"},{"key":"e_1_2_10_216_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat9365"},{"key":"e_1_2_10_217_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b01215"},{"key":"e_1_2_10_218_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.05.084"},{"key":"e_1_2_10_219_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.01.012"},{"key":"e_1_2_10_220_2","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.4524293"},{"key":"e_1_2_10_221_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.04.010"},{"key":"e_1_2_10_222_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202100286"},{"key":"e_1_2_10_223_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.2255"},{"key":"e_1_2_10_224_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.673683"},{"key":"e_1_2_10_225_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm5070062"},{"key":"e_1_2_10_226_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.100"},{"key":"e_1_2_10_227_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.2225"},{"key":"e_1_2_10_228_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0380-9"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/5247814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bmri\/5247814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/5247814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:07:05Z","timestamp":1774436825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bmri\/5247814"}},"subtitle":[],"editor":[{"given":"Baisakhi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":228,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/bmri\/5247814"],"URL":"https:\/\/doi.org\/10.1155\/bmri\/5247814","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5247814"}}