{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:22:51Z","timestamp":1773008571224,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007684","name":"Ministry of Education and Science of Ukraine","doi-asserted-by":"publisher","award":["123U101850"],"award-info":[{"award-number":["123U101850"]}],"id":[{"id":"10.13039\/501100007684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>The Aim<\/jats:title>\n                    <jats:p>\n                      We are aimed at examining the potential link between the\n                      <jats:italic>VDR<\/jats:italic>\n                      gene polymorphism rs7975232 and the occurrence of benign breast disease in the Ukrainian population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and six patients with BBD and 221 control subjects were enrolled in this case\u2010control study. PCR\u2010RFLP was used for\n                      <jats:italic>VDR<\/jats:italic>\n                      gene rs7975232 genotyping. SPSS software package (Version 25.0, IBM, USA) was used for data analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a research relationship between the rs7975232 polymorphism and BPBD and other influencing factors as family history burden, predisposing factors, and blood estradiol levels, smoking, gynecological pathology, hormone intake, goiter, or mastodynia. In individuals younger than 40, heterozygotes have a higher BPBD risk compared with both homozygotes (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04), but this risk is not statistically significant after adjusting for BMI (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.16). Conversely, for those aged 40 and above, heterozygotes have a lower BPBD risk compared with both homozygotes (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.036), and this significant association remains after BMI adjustment (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012); additionally, recessive allele homozygotes have a higher BPBD risk compared wiht major allele carriers post\u2010BMI adjustment (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.033).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Obtained data suggested that rs7975232 polymorphism of the\n                      <jats:italic>VDR<\/jats:italic>\n                      gene can be a possible genetic marker for the development of benign proliferative breast disease in the Ukrainian population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/5536121","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:26:58Z","timestamp":1773001618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Link Between\n                    <i>VDR<\/i>\n                    Gene rs7975232 Polymorphism and Benign Proliferative Breast Disease in Ukrainian Population"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2104-8412","authenticated-orcid":false,"given":"Olha","family":"Obukhova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-3052","authenticated-orcid":false,"given":"Mykola","family":"Kyrychenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-1698","authenticated-orcid":false,"given":"Ivan","family":"Lukavenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-6997","authenticated-orcid":false,"given":"Viktoriia Yu.","family":"Harbuzova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9145-6"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044383"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djhs105"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200404000-00003"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000132"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0278"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0497-9"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152013804487434"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-023-01541-8"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-46227-7_4"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-0970-T"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtumed.2021.12.006"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.04.008"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.32471\/clinicaloncology.2663-466X.39-3.27529"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.7.1163"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1577-y"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.05.014"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.02.024"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2020.21.9.2667"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-483"},{"key":"e_1_2_12_22_2","doi-asserted-by":"crossref","unstructured":"FomenkoI. H. HarbuzovaV. Y. ObukhovaO. A. PlakhtiienkoI. A. andPivenS. N. The Association of a\u0440ai-polymorphism of Vitamin D Receptor Gene (VDR) With Development of Generalized Parodontitis in Ukrainianpopulation 2019 72 no. 7 1253\u20131257 https:\/\/doi.org\/10.36740\/wlek201907105 31398151.","DOI":"10.36740\/WLek201907105"},{"key":"e_1_2_12_23_2","doi-asserted-by":"crossref","unstructured":"ObukhovaO. A. AtamanA. V. ZavadskaM. M. PivenS. M. andLevchenkoZ. M. The Associason of Vitamin D Receptor Gene (VDR) Polymorphisms With High Blood Pressure in Stroke Patients of Ukrainian Population Wiadomosci Lekarskie 2020 73 no. 11 2349\u20132353 https:\/\/wiadlek.pl\/wp-content\/uploads\/archive\/2020\/WLek202011105.pdf.","DOI":"10.36740\/WLek202011105"},{"key":"e_1_2_12_24_2","doi-asserted-by":"crossref","unstructured":"GarbuzovaV. Y. StroyD. A. DosenkoV. E. ObukhovaO. A. andAtamanO. V. Association of Allelic Polymorphisms of Genes Matrix Gla-Protein System With Ischemic Atherothrombotic Stroke Fiziolohichny\u012d Zhurnal 2015 61 no. 1 19\u201327 https:\/\/doi.org\/10.15407\/fz61.01.019 2-s2.0-84930789488.","DOI":"10.15407\/fz61.01.019"},{"key":"e_1_2_12_25_2","first-page":"12","article-title":"The Clinical Significance of pvuii Polymorphism Estradiol Receptor Alpha Gene to Improve Diagnosis of Proliferative Forms of Benign Breast Dysplasia","volume":"238","author":"Lukavenko I. M.","year":"2015","journal-title":"Georgian Medical News"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/5536121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bmri\/5536121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/5536121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:27:04Z","timestamp":1773001624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bmri\/5536121"}},"subtitle":[],"editor":[{"given":"Baisakhi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/bmri\/5536121"],"URL":"https:\/\/doi.org\/10.1155\/bmri\/5536121","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5536121"}}