{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:14:23Z","timestamp":1771236863750,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Breast cancer, particularly estrogen receptor\u2010positive subtypes, is a leading cause of cancer\u2010related mortality worldwide. Aromatase inhibitors, which target estrogen biosynthesis, are a cornerstone of therapeutic intervention.\n                    <jats:italic>Panax ginseng<\/jats:italic>\n                    , a widely recognized medicinal herb, contains bioactive compounds known as ginsenosides, which possess various pharmacological activities, including anticancer properties. This study is aimed at evaluating the potential of ginsenosides and their derivatives from\n                    <jats:italic>Panax ginseng<\/jats:italic>\n                    as aromatase inhibitors for breast cancer treatment through\n                    <jats:italic>in silico<\/jats:italic>\n                    methods. Molecular docking studies were conducted to investigate the binding affinities of ginsenosides to aromatase, a critical enzyme in estrogen biosynthesis. The results indicated that several ginsenosides exhibited strong binding affinities, with Protopanaxadiol demonstrating the highest affinity (\u221210.0\u2009kcal\/mol) and an estimated\n                    <jats:italic>K<\/jats:italic>\n                    <jats:italic>i<\/jats:italic>\n                    value of 46.77\u2009nM. Molecular dynamics simulations confirmed the stability of the protopanaxadiol\u2010aromatase complex, highlighting its consistent binding interactions and minimal structural fluctuations. Pharmacokinetic evaluations suggested that most ginsenosides adhered to drug\u2010likeness criteria, although certain derivatives showed deviations that may affect bioavailability. However, toxicity predictions revealed a predominantly low toxicity profile, with some concerns related to hepatotoxicity and mutagenicity for specific compounds. The findings from this study highlight the potential of ginsenosides and their derivatives as viable candidates and protopanaxadiol as a promising lead compound for further experimental investigation as aromatase inhibitors, offering a promising alternative or adjunct to conventional breast cancer therapies.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/5538317","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:29:22Z","timestamp":1771234162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Ginsenosides and Their Derivatives From\n                    <i>Panax ginseng<\/i>\n                    as Aromatase Inhibitors for Breast Cancer Treatment\u2014An\n                    <i>in silico<\/i>\n                    study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4957-0121","authenticated-orcid":false,"given":"Jayasri Gokila","family":"Madhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9141-2997","authenticated-orcid":false,"given":"Surya","family":"Sekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1572-8412","authenticated-orcid":false,"given":"Rajeswari Nambirajan","family":"Akshaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4842-3288","authenticated-orcid":false,"given":"Khavyanjali","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5519-7961","authenticated-orcid":false,"given":"Kavin","family":"Kirupanandasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7156-0331","authenticated-orcid":false,"given":"Kiruthika","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5008-9715","authenticated-orcid":false,"given":"Nancy","family":"Jenifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-3412","authenticated-orcid":false,"given":"Benedict Christopher","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_2_2","volume-title":"Breast Cancer","author":"Orrantia-Borunda E.","year":"2022"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2024.2335301"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2011.02.001"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2021\/e2846"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/pr9081344"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14458"},{"key":"e_1_2_11_8_2","first-page":"4965","article-title":"Inhibitory Effect of Ginseng on Breast Cancer Cell Line Growth Via Up-Regulation of Cyclin Dependent Kinase Inhibitor, p21 and p53","volume":"17","author":"Shabanah O. 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