{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:55:06Z","timestamp":1791194106822,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":173,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010679","name":"Pasteur Institute of Iran","doi-asserted-by":"publisher","award":["1169"],"award-info":[{"award-number":["1169"]}],"id":[{"id":"10.13039\/501100010679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    In this investigation, we focused on generating innovative antifungal agents inspired by terbinafine, a prominent allylamine that inhibits squalene epoxidase and is a crucial enzyme in the biosynthesis of fungal ergosterol. Utilizing computational methods such as molecular docking and molecular dynamics (MD) simulations, we designed and synthesized a collection of enyne derivatives featuring aromatic side chains. The choice of these compounds was influenced by their anticipated interactions with squalene epoxidase, informed by comprehensive in silico assessments. The synthesized derivatives were analyzed using\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR, and mass spectrometry techniques. Among the synthesized series, Compound 2b (1,6\u2010bis[(4\u2010methylphenyl)methyl] (2E)\u2010hex\u20102\u2010en\u20104\u2010ynedioate) exhibited potent antifungal activity, demonstrating a minimum inhibitory concentration (MIC) of 0.0391\u20130.7176\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M\/mL against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    ,\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    , and\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    . These findings highlight the promising strategy of applying these novel compounds, based on the structural design of terbinafine, as viable candidates for antifungal treatment. This approach demonstrates a significant advancement in the design of antifungal agents targeting squalene epoxidase and suggests promising avenues for further development.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/5560073","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:01:17Z","timestamp":1782277277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Synthesis of 2\u2010En\u20104\u2010Ynedioate Compounds as Novel and Potential Antifungal Agents"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8511-0289","authenticated-orcid":false,"given":"Mohadese","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Department of Chemistry College of Science University of Tehran  Tehran Iran  ut.ac.ir"},{"name":"Clinical Research Department Pasteur Institute of Iran  Tehran Iran  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