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SARS\u2010CoV\u20102 infection triggers innate and adaptive immune responses, but excessive cytokine release can drive hyperinflammation, acute respiratory distress syndrome and poor clinical outcomes. Although serological and molecular assays, such as ELISA and RT\u2010qPCR, remain central to COVID\u201019 diagnostics, they have limited capacity to reveal host\u2013pathogen interactions at the tissue level. Therefore, profiling the human lung proteome offers a powerful strategy to identify molecular signatures associated with viral pathogenesis and disease severity. This review emphasises emerging technologies that advance lung proteome profiling during SARS\u2010CoV\u20102 infection. Novel strategies include phage display for high\u2010throughput identification of antibody\u2013antigen interactions, yeast two\u2010hybrid for mapping virus\u2013host protein interactions and lateral flow immunoassays for rapid, point\u2010of\u2010care detection. 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