{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:36:59Z","timestamp":1770046619641,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["24058"],"award-info":[{"award-number":["24058"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["24328"],"award-info":[{"award-number":["24328"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral cancer, particularly oral squamous cell carcinoma (OSCC), is a major global health concern, with late\u2010stage diagnoses significantly lowering survival rates. Salivary gland tumors (SGTs), though less common, pose diagnostic challenges due to their varied presentation. This study investigates the role of interleukin\u201035 (IL\u201035) in OSCC and SGTs, aimed at assessing its potential as a biomarker for early detection and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted, including 65 OSCC patients, 65 SGTs patients, and 50 healthy individuals as a control group. Inclusion criteria included age over 18 years, negative HPV confirmation, and histopathologically confirmed cancer diagnosis (SGT or OSCC). Blood samples were collected from all participants. Serum IL\u201035 levels were measured using the ELISA kit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u201035 levels varied significantly between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), with the lowest levels detected in the SGT group. Pairwise comparisons revealed that IL\u201035 levels were significantly lower in the SGTs patients (5.45 \u00b1 6.03\u2009pg\/mL) compared to both the OSCC group (9.21 \u00b1 10.81\u2009pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) and the control group (10.50 \u00b1 11.77\u2009pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004). IL\u201035 levels were significantly lower in patients with malignant SGTs (5.45 \u00b1 6.03\u2009pg\/mL) compared to healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). There were no significant differences in IL\u201035 levels between benign and malignant SGTs (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.133). In OSCC patients, IL\u201035 levels did not significantly differ from those in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). Furthermore, OSCC tumor characteristics, including tumor origin and lymphatic involvement, showed no significant correlation with IL\u201035 levels (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study indicates that IL\u201035 levels are notably reduced in SGTs compared to healthy individuals. However, no significant difference was observed between benign and malignant SGTs. The absence of significant correlation in OSCC patients suggests that IL\u201035 may have a minor role in this type of cancer, highlighting the potential need for other biomarkers to improve early detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/6091357","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:04:24Z","timestamp":1770008664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Interleukin\u201035 Levels in Oral Squamous Cell Carcinoma and Salivary Gland Tumors: Implications for Early Detection and Prognosis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5047-4018","authenticated-orcid":false,"given":"Maryam","family":"Zahed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1388-3883","authenticated-orcid":false,"given":"Sara","family":"Maroofi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannan","family":"Ghapanchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijan","family":"khademi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Ghaderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Javad","family":"Fattahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloofar","family":"Hayati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fardad","family":"Khoubani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061321"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.186696"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2020.101034"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.15.e880"},{"key":"e_1_2_15_6_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.37284\/eajhs.6.1.1315","article-title":"Pattern of Salivary Gland Tumours Among Patients Attending Otorhinolaryngology and Maxillofacial Services at Tertiary Hospital in Tanzania, A Cross-Sectional Study","volume":"6","author":"Massawe E. 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