{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:57:54Z","timestamp":1786121874599,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":218,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Bone repair requires injectable biomaterials that solidify in situ, resist infection, and provide osteoconductive reinforcement. However, it remains unknown whether a photo\u2010crosslinkable hydrogel can combine silver nanoparticle functionality with hydroxyapatite\u2010driven mechanical support for mandibular regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An injectable hydrogel was synthesized from gelatin methacrylate and methacrylated Farsi gum, functionalized with silver nanoparticles and hydroxyapatite (0%, 5%, and 10%\n                      <jats:italic>w<\/jats:italic>\n                      \/\n                      <jats:italic>w<\/jats:italic>\n                      ). Chemistry and phase integration were verified by Fourier\u2010transform infrared spectroscopy, x\u2010ray diffraction, and proton nuclear magnetic resonance; swelling, degradation, porosity, and compression (including cyclic loading) were assessed at 5 and 12 weeks using radiography and histology; and rat mandibular healing was assessed at 5 and 12 weeks by radiography and histology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Spectroscopic and diffraction analyses confirmed incorporation of all components. All formulations showed controlled swelling\/degradation with porous architectures. Hydroxyapatite increased compressive performance, with 10%\n                      <jats:italic>w<\/jats:italic>\n                      \/\n                      <jats:italic>w<\/jats:italic>\n                      yielding the highest strength and elastic recovery under repeated compression. In rat mandibles, the 10% hydroxyapatite hydrogel supported bone regeneration on radiographic and histologic assessment at Weeks 5 and 12.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data show a single injectable platform that combines antimicrobial and anti\u2010inflammatory functions with osteoconductive support, paving the way for minimally invasive craniofacial and orthopedic bone repair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/6156533","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:03:31Z","timestamp":1786086211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Injectable Gelatin\u2013Farsi Gum Hydrogels Functionalized With Hydroxyapatite for Biomimetic Oral Bone Regeneration"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6843-592X","authenticated-orcid":false,"given":"Mohammad Amin","family":"Amiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3115-075X","authenticated-orcid":false,"given":"Mozhgan","family":"Abedanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Sajad","family":"Daneshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-2498","authenticated-orcid":false,"given":"Asma","family":"Najibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-8322","authenticated-orcid":false,"given":"Moein","family":"Zarei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2970-1851","authenticated-orcid":false,"given":"Saeed","family":"Afzoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-7279","authenticated-orcid":false,"given":"Fatemeh","family":"Akbarizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radmehr","family":"Kazemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7221-0711","authenticated-orcid":false,"given":"Kiarash","family":"Fereidouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Norouzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-8985","authenticated-orcid":false,"given":"Seyyed Vahid","family":"Niknezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8896-1225","authenticated-orcid":false,"given":"Fatemeh","family":"Lavaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA02557K"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2004.04.005"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.03.017"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-017-0084-4"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12998"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.5005\/JP-Journals-10012-1095"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-019-0157-y"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2013.03.005"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jfb10010003"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-020-0204-2"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.03.064"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma9100797"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA02695A"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep31036"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-023-00422-6"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/cryst11020149"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/nano11051152"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bprint.2022.e00196"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b01433"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S354127"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116639"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2017.06.006"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.05.022"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.09.060"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-020-04462-x"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rby023"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2017.01.074"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2021.102225"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.07.007"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01965E"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2022.04.020"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b10673"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2018.04.173"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111694"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.112422"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10924-021-02367-0"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpta.2020.100003"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2005.10.090"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2010.03.112"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym12020501"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma13173735"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma00182a019"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2021.109396"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1219460"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.110163"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.02.020"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ab9422"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1053491"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201101662"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.05.060"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22803"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S245500"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(96)00183-4"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10121666"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23486"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2020.04.021"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/mba2.51"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma11081345"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym10111290"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/6156533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bmri\/6156533","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/6156533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:03:32Z","timestamp":1786086212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bmri\/6156533"}},"subtitle":[],"editor":[{"given":"Yoel A.","family":"Klug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/bmri\/6156533"],"URL":"https:\/\/doi.org\/10.1155\/bmri\/6156533","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6156533"}}