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Propolis, a natural resin with known antimicrobial and anti\u2010inflammatory properties, suffers from poor solubility and bioavailability. This study evaluated a\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010cyclodextrin\u2013propolis complex designed to enhance delivery and therapeutic efficacy in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010infected patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In a double\u2010blind, randomized clinical trial at Hamadan University of Medical Sciences, biopsy\u2010confirmed\n                      <jats:italic>H. pylori<\/jats:italic>\n                      patients received standard quadruple therapy plus omeprazole. The treatment group (\n                      <jats:italic>n<\/jats:italic>\n                      = 28) also received 250\u2009mg\/day of the\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010cyclodextrin\u2013propolis complex for 2 months; the control group (\n                      <jats:italic>n<\/jats:italic>\n                      = 12) received placebo capsules. Outcomes were assessed using fecal antigen tests and gastrointestinal symptom questionnaires 2 months posttreatment. Characterization of the complex was performed using FESEM, FTIR, and drug release profiling in PBS (pH\u20097.4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The complex demonstrated a successful formation and a sustained propolis release profile. Clinically, 57.1% of treated patients achieved negative antigen tests and symptom resolution, compared with 41.6% in the control group. Adverse effects were mild and comparable between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings suggest that the\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010cyclodextrin\u2013propolis complex may serve as an effective natural adjunct to standard\n                      <jats:italic>H. pylori<\/jats:italic>\n                      treatment, offering potential benefits in eradication rates and symptom relief.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Iranian Registry of Clinical Trials (IRCT): 20230503058065N1.<\/jats:p>\n                  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