{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:42:33Z","timestamp":1792651353405,"version":"4.5.0"},"reference-count":119,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":293,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Vector\u2010borne diseases remain a critical global health concern, particularly in tropical and subtropical regions, where socioeconomic conditions often favor vector proliferation. Pyriproxyfen, a juvenile hormone analog used as a larvicide against\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , is known for its fast\u2010acting efficacy, low toxicity, and favorable environmental profile. Because of these properties, pyriproxyfen was chosen as a reference scaffold to explore structurally and electrostatically similar compounds through ligand\u2010based virtual screening. The ChemBridge DIVERSet\u2010CL database (\u2248\u2009100,000 compounds) was used, applying ROCS for shape similarity and EON for electrostatic potential comparison. A total of 35 top\u2010ranked molecules were identified based on superior pharmacokinetic and toxicological properties compared with the reference. Subsequently, molecular docking analyses were performed to assess binding affinity and interaction modes with selected biological targets: acetylcholinesterase (AChE) and juvenile hormone\u2010binding proteins from various organisms. Two compounds, LMQC3 and LMQC23, demonstrated strong binding affinities to AChE enzymes from\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    (\u221211.4 and \u221210.6\u2009kcal\/mol),\n                    <jats:italic>Anopheles gambiae<\/jats:italic>\n                    (\u221210.19 and \u221210.21\u2009kcal\/mol), and humans (\u22129.91 and \u22129.95\u2009kcal\/mol). Additionally, they exhibited high affinity toward the juvenile hormone protein in\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    (\u221211.83 and \u221211.94\u2009kcal\/mol), surpassing reference ligands. Both molecules established key interactions with catalytic residues, supporting their potential dual inhibitory activity. These findings indicate that LMQC3 and LMQC23 are potential promising insecticidal candidates with multitarget potential, showing favorable predicted target\u2010binding profiles and encouraging in silico pharmacokinetic and toxicity characteristics. Their development could contribute to next\u2010generation mosquito control strategies and help mitigate the spread of arbovirus\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/6490830","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:06:57Z","timestamp":1792649217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scaffold\u2010Hunting From Pyriproxyfen: A Biochemoinformatic Route to Novel Insecticidal Leads"],"prefix":"10.1155","volume":"2026","author":[{"given":"Edla L. V. 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