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As a result, the usage of antidepressant drugs is growing day by day. However, the effect of this medication on glucose homeostasis is not clear. We investigated the impact of a combined antidepressant drug flupentixol\u2010melitracen on glucose levels and the expression of associated genes in\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    . The flies were reared in control and treatment vials having standard and drug\u2010treated food. The glucose oxidase method showed significantly reduced glucose levels in the treated\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . The Ct values obtained from qPCR for the relative quantification of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    insulin\u2010like peptide (DILP) genes,\n                    <jats:italic>DILP5<\/jats:italic>\n                    and\n                    <jats:italic>DILP6<\/jats:italic>\n                    , were analyzed using the 2\n                    <jats:sup>\n                      \u2212\n                      <jats:italic>\u0394\u0394<\/jats:italic>\n                      CT\n                    <\/jats:sup>\n                    method. The\n                    <jats:italic>DILP5<\/jats:italic>\n                    gene was expressed slightly higher in the antidepressant\u2010treated group, though the expressions of the DILP genes appeared statistically insignificant. The current study suggests that anxiolytics and antidepressant drugs might be associated with the insulin signaling pathway, which is crucial for growth, glucose regulation, and other fundamental metabolic processes. Further study is required to determine the expression pattern of all DILP and other genes that might affect glucose homeostasis.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/6698526","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:15:44Z","timestamp":1777562144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a Combined Antidepressant Drug Flupentixol\u2013Melitracen on Glucose Level and Expression of Insulin\u2010Like Peptide Genes\n                    <i>DILP5<\/i>\n                    and\n                    <i>DILP6<\/i>\n                    in\n                    <i>Drosophila melanogaster<\/i>"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-4199","authenticated-orcid":false,"given":"Azizul Islam","family":"Barkat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1271-7781","authenticated-orcid":false,"given":"Khandaker Asif","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7880-0823","authenticated-orcid":false,"given":"Sumaiya","family":"Akter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8604-0510","authenticated-orcid":false,"given":"Md","family":"Shamsudduha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5307-8089","authenticated-orcid":false,"given":"Farhin Momtaz","family":"Riana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5569-7779","authenticated-orcid":false,"given":"Rabeya Bosri","family":"Mehe Jabin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0908-5680","authenticated-orcid":false,"given":"Mahmuda","family":"Begum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-1097","authenticated-orcid":false,"given":"Mohammad Shamimul","family":"Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00653-0"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.08.002"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2025.03.074"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284389"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.74318"},{"key":"e_1_2_10_6_2","volume-title":"Antidepressants","author":"Sheffler Z. 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