{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:57:15Z","timestamp":1779317835678,"version":"3.51.4"},"reference-count":89,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005071","name":"Shiraz University","doi-asserted-by":"publisher","award":["0GCB6M1899"],"award-info":[{"award-number":["0GCB6M1899"]}],"id":[{"id":"10.13039\/501100005071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The relationship between endometriosis and cardiovascular disease (CVD) is well established. However, the effects of various exercise training modalities and the anti\u2010inflammatory effects of pentoxifylline (PTX) remain inadequately understood. This investigation is aimed at evaluating the effects of PTX, both independently and in conjunction with high\u2010intensity interval training (HIIT) and moderate\u2010intensity continuous training (MICT), on lipid and inflammatory markers including triglycerides (TGs), total cholesterol (TC), high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol (LDL\u2010C), and C\u2010reactive protein (CRP) in a rat model of endometriosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods:<\/jats:bold>\n                    Sprague\u2013Dawley\u2019s rats were divided into two primary groups: the healthy control group that received no intervention and the induced endometriosis group. Endometriosis was surgically induced in rats, and those with confirmed endometriotic lesions were further categorized into six groups: control, MICT, drug of PTX (D), MICT+D, HIIT, and HIIT+D. Two weeks after laparotomy, PTX consumption and exercise training were performed for 8 weeks. PTX was administered orally at 100\u2009mg\/kg\/day. MICT and HIIT sessions were conducted 5 days per week, with MICT beginning at 55% of maximum capacity for 31\u2009min in the first week and progressing to 70% of maximum capacity for 46\u2009min by the eighth week. HIIT sessions consisted of 2\u2009min of running followed by 1\u2009min of passive rest at 85% of maximum capacity, starting with seven intervals in the first week and increasing to twelve by the end of the eighth week. The macroscopic size of endometriosis lesions was measured, and cardiovascular risk factors, including hs\u2010CRP, TC, TG, HDL\u2010C, and LDL\u2010C, were assessed in serum samples.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The induction of endometriosis was associated with elevated cardiovascular risk factors, including hs\u2010CRP, TC, and TG. HIIT+D significantly decreased lesion volume (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001, 95\n                    <jats:italic>%<\/jats:italic>\n                    confidence\u2009interval\u2009(CI) = 57.239\u201394.718), hs\u2010CRP (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.049, CI = \u221254.083\u2009to \u2212 29.478), TC (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.045, CI = \u221238.607\u2009to \u2212 25.392), and TG (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.042, CI = 25.531\u201355.801). PTX significantly decreased lesion volume (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001, CI\u2009=34.709\u201373.919) and TC (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.016, CI = \u221245.153\u2009to \u2212 30.179).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    All interventions except MICT reduced lesion volume, whereas only HIIT+PTX and PTX, in the order of importance, improved some cardiovascular risk indices in the rat model of endometriosis.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/6742953","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:33:16Z","timestamp":1741743196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010Intensity Interval Training Enhances the Positive Effect of Pentoxifylline on Lipid Profile and Inflammatory Markers in an Endometriosis Animal Model"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0122-204X","authenticated-orcid":false,"given":"Zahra","family":"Salehpoor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-9461","authenticated-orcid":false,"given":"Maryam","family":"Koushkie Jahromi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.4274\/tjps.galenos.2021.52284"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020450"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2021.1919764"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/0167482X.2024.2441196"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5232"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab303"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9010054"},{"key":"e_1_2_10_8_2","first-page":"118","article-title":"Association of dyslipidemia with endometriosis: a case control study","volume":"32","author":"Nahar K.","year":"2023","journal-title":"Mymensingh Medical Journal: MMJ"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.2991\/hsic-17.2017.68"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2023.04.001"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.03.040"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054653"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.47489\/PSZMC-836362-23-28"},{"key":"e_1_2_10_14_2","first-page":"781","article-title":"Modulation of blood hemostasis by concurrent training in obese women with low-mobility","volume":"29","author":"Khademi A.","year":"2019","journal-title":"The Journal of Urmia University of Medical Sciences"},{"key":"e_1_2_10_15_2","unstructured":"FallahzadehF. 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