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Since antiquity, medicinal plants have been used as a source of immune\u2010boosting medicines with fewer side effects. These medicinal plants, for example,\n                    <jats:italic>Curcuma longa<\/jats:italic>\n                    ,\n                    <jats:italic>Camellia sinensis<\/jats:italic>\n                    ,\n                    <jats:italic>Artemisia annua<\/jats:italic>\n                    , and\n                    <jats:italic>Andrographis paniculata<\/jats:italic>\n                    , have been used to treat immune system disorders such as multiple sclerosis, psoriasis, lupus, and organ transplantation. Herein, we review the currently accessible medicinal plants, their phytoconstituents, and underlying mechanisms of immunomodulation.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/6998034","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:06:44Z","timestamp":1770098804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8789-9378","authenticated-orcid":false,"given":"Gurdeep","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-9215","authenticated-orcid":false,"given":"Vikas","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7752-0552","authenticated-orcid":false,"given":"Blessing Nnenna","family":"Udeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20160017"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101324"},{"key":"e_1_2_14_3_2","article-title":"Role of Medicinal Plants as Immunostimulants in Health and Disease","volume":"1","author":"Sethi J.","year":"2015","journal-title":"Annals of Medicinal Chemistry Research"},{"key":"e_1_2_14_4_2","first-page":"45","article-title":"Immunostimulants: Types and Functions","volume":"4","author":"Shahbazi S.","year":"2016","journal-title":"Journal of Medical Microbiology and Infectious Diseases"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac199062071217"},{"key":"e_1_2_14_6_2","first-page":"179","article-title":"Immunomodulators: A Review of Studies on Indian Medicinal Plants and Synthetic Peptides","volume":"65","author":"Agarwal S. 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