{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:43:30Z","timestamp":1782906210799,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":180,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["141911\/2025-5"],"award-info":[{"award-number":["141911\/2025-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","doi-asserted-by":"publisher","award":["0011\/2022"],"award-info":[{"award-number":["0011\/2022"]}],"id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study was aimed at evaluating the potential otoprotective effects of resveratrol (Changsha Huir Biological\u2010Tech) on noise\u2010induced hearing loss (NIHL) in a Wistar rat model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study employed a randomized controlled design. The noise used for stimulation was white noise, centered at a frequency of 4000\u2009Hz (3564\u20134490\u2009Hz), with an intensity of 100\u2009dB SPL, for a period of 10 consecutive days at 8\u2009h\/day. Thirty rats were randomly assigned to three groups: a control nonexposed\u2010to\u2010noise group (\n                      <jats:italic>n<\/jats:italic>\n                      = 10) that received a vehicle solution of DMSO (dimethyl sulfoxide) (Sigma\u2010Aldrich), a noise\u2010exposed study group (\n                      <jats:italic>n<\/jats:italic>\n                      = 10) that received a vehicle solution of DMSO, and a resveratrol study group that was exposed to noise and received 10\u2009mg\/kg\/day of resveratrol. All groups underwent distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) assessments at three time points: initial examination (D0), examination after 10 consecutive days of noise exposure (D15), and examination after 15 days of acoustic rest (D30). Histological evaluations were conducted on cochlear tissues after euthanasia. Statistical analyses were performed using Prism software to determine differences between groups and across time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The amplitude values, signal\u2010to\u2010noise ratios of DPOAE, ABR thresholds, and cochlear morphology between the experimental and control groups were significantly different from each other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest that resveratrol exerts a partial otoprotective effect, possibly delaying the onset of NIHL. However, further research, particularly molecular research, is needed to better understand its therapeutic mechanism and its specific impact on auditory metabolic processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/7605759","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:43:46Z","timestamp":1782902626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resveratrol Mitigates Noise\u2010Induced Cochlear Damage and Delays Hearing Loss in Wistar Rats"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-4988","authenticated-orcid":false,"given":"Ana Carolina Odorizzi","family":"Zica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-3353","authenticated-orcid":false,"given":"Gabriela Guenther Ribeiro","family":"Novanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9754-3786","authenticated-orcid":false,"given":"Maria Luiza Queiroz","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6758-300X","authenticated-orcid":false,"given":"Andressa","family":"Caram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8594-0015","authenticated-orcid":false,"given":"Rafael Rocha","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7677-772X","authenticated-orcid":false,"given":"Selma Aparecida Souza","family":"Kuckelhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8113-7222","authenticated-orcid":false,"given":"Lucieny Silva Martins","family":"Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-1303","authenticated-orcid":false,"given":"Andr\u00e9 Luiz Lopes","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_11_1_2","volume-title":"Ru\u00eddo Urbano E Efeitos N\u00e3o Auditivos Na Sa\u00fade Da Popula\u00e7\u00e3o: Revis\u00e3o De Literatura","author":"Amorim L. 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