{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:26:54Z","timestamp":1787304414896,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":232,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Urinary tract infections (UTIs) are one of the commonly encountered infectious diseases globally, affecting approximately 150 million individuals each year. The rise of multidrug\u2010resistant (MDR) particularly extended spectrum beta\u2010lactamase (ESBL) producing Enterobacterales has made the management of UTI more difficult and this is becoming a common public health concern worldwide. The study is aimed at assessing the prevalence, antimicrobial resistance, and extended\u2010spectrum beta\u2010lactamase\u2013producing Enterobacterales among patients with symptoms of UTI at Wudassie Advanced Medical Laboratory, Addis Ababa, Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A laboratory based cross\u2010sectional study was conducted from April to July 2025. A total of 502 urine specimens from UTI suspected patients were included in the study. The identification of Enterobacterales was done using MALDI\u2010TOF MS. Antimicrobial susceptibility testing was performed using the Kirby\u2013Bauer disc diffusion technique. Combined disc test (CDT) was used for confirmation of ESBL producing Enterobacterales. Data was entered in Epidata version 4.6 and analyzed using SPSS Version 27.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Among 502 patients presenting with clinical symptoms of UTI, 29.4% (148\/502) had positive culture for Enterobacterales. The predominant species isolated were\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      103 (69.6%) and\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      25 (16.8%). The prevalence of extended spectrum\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010lactamases\u2013producing Enterobacterales (ESBLs\u2010E) was 65.5% (97\/148: 95% CI: 57.8%\u201073.2%). The highest proportion (92.3%) of ESBL\u2010producing isolate among inpatients was\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      . MDR was also detected in 82.4% of the isolates from this study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings highlight a high prevalence of MDR\u2010 and ESBL\u2010producing Enterobacterales causing UTI in Ethiopia. This finding emphasizes a critical need to implement comprehensive surveillance systems in hospital settings to enable the detection and tracking of MDR Enterobacterales. Future research needs to be conducted to direct policies on the implementation of antibiotic stewardship programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/7993514","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:55:20Z","timestamp":1787302520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extended Spectrum Beta\u2010Lactamase Production and Multidrug\u2010Resistant Enterobacterales Among Patients With Symptoms of Urinary Tract Infection in Addis Ababa, Ethiopia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9998-1848","authenticated-orcid":false,"given":"Tamirat","family":"Tamiru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6420-7272","authenticated-orcid":false,"given":"Yordanos","family":"Getachew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1986-9505","authenticated-orcid":false,"given":"Sami","family":"Sebri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regasa","family":"Diriba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1134-4616","authenticated-orcid":false,"given":"Mekdelawit","family":"Fisseha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-2163","authenticated-orcid":false,"given":"Tadesse","family":"Shume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassu","family":"Desta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_20_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-03071-4"},{"key":"e_1_2_20_2_2","first-page":"163","article-title":"Prevalence of Urinary Tract Infections (UTI) Among Patients Attending Dalhatu Araf Specialist Hospital, Lafia, Nasarawa State, Nigeria","volume":"1","author":"Kolawole A. 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