{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:49:11Z","timestamp":1776275351577,"version":"3.50.1"},"reference-count":96,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":104,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    This study investigates the bioactive components and biological activities of the methanolic husk extract of\n                    <jats:italic>Nypa fruticans<\/jats:italic>\n                    Wurmb (MNF) through gas chromatography\u2013mass spectrometry (GC\u2010MS) analysis. The MNF extract was identified to contain several bioactive components, including alkaloids, glycosides, phenols, tannins, and resins, as established through preliminary phytochemical screening tests. After finding the presence of antioxidant components in the qualitative antioxidative assay, we went to conduct quantitative tests where the total contents of phenolics, flavonoids, and tannins were estimated as 179.43 \u00b1 3.99\u2009mg GAE\/g, 179.43 \u00b1 3.99\u2009mg QE\/g, and 29.25 \u00b1 0.29\u2009mg TAE\/g, respectively. The extract demonstrated notable antioxidant activity in DPPH free radical scavenging (IC\n                    <jats:sub>50<\/jats:sub>\n                    36.28\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL) and ferric reducing antioxidant power (83.27\n                    <jats:italic>%<\/jats:italic>\n                    \u00b1 0.02\n                    <jats:italic>%<\/jats:italic>\n                    reduction) assays. The extract demonstrated notable in vitro anti\u2010inflammatory and antiarthritic properties in a dose\u2010dependent manner, as indicated by human red blood cell (HRBC) membrane stabilization (74.63\n                    <jats:italic>%<\/jats:italic>\n                    \u00b1 0.84\n                    <jats:italic>%<\/jats:italic>\n                    at 5000\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL) and protein denaturation (88.77\n                    <jats:italic>%<\/jats:italic>\n                    \u00b1 0.31\n                    <jats:italic>%<\/jats:italic>\n                    inhibition at 500\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL), relative to standards. The anti\u2010inflammatory efficacy of MNF extract was confirmed via an in vivo carrageenan\u2010induced inflammatory study, showing an 85.49% reduction in edema at the maximum dosage of 600\u2009mg\/kg. The extract demonstrated significant (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01, and\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001) and dose\u2010dependent analgesic effects in acetic acid\u2013induced writhing and formalin\u2010induced pain assays. Molecular docking studies conducted with the selected compounds against potential targets identified 1\u2010(3,6,6\u2010trimethyl\u20101,6,7,7a\u2010tetrahydrocyclopenta[c]pyran\u20101\u2010yl) ethanone as the best candidate with promising analgesic and anti\u2010inflammatory potential, demonstrated by its high binding affinity comparable to or exceeding that of the selected standard drugs. Our findings indicate that\n                    <jats:italic>N. fruticans<\/jats:italic>\n                    fruit husk may serve as a viable source of natural chemicals possessing antioxidant, analgesic, anti\u2010inflammatory, and antiarthritic properties, demonstrating potential therapeutic effects in alleviating diseases associated with inflammatory responses.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/8861594","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:53:33Z","timestamp":1776272013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant, Anti\u2010inflammatory, Analgesic, and Antiarthritic Potentialities of Methanolic Extract of Fruit Husk of\n                    <i>Nypa fruticans<\/i>\n                    Wurmb, Established by In Silico Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-2739","authenticated-orcid":false,"given":"Farhana Alam","family":"Ripa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3377-6315","authenticated-orcid":false,"given":"Ajoy Paul","family":"Adar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-3381","authenticated-orcid":false,"given":"Adwiza Chakraborty","family":"Bishakha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5585-7066","authenticated-orcid":false,"given":"Nashrah","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2239-976X","authenticated-orcid":false,"given":"Mehrin Haque","family":"Tanisha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1301-1721","authenticated-orcid":false,"given":"Nishat Zareen","family":"Khair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2403-5772","authenticated-orcid":false,"given":"Zara","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3006-6206","authenticated-orcid":false,"given":"Asef","family":"Raj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8938-8894","authenticated-orcid":false,"given":"Israt Jahan","family":"Bulbul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4179487"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43994-024-00160-y"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4495688"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225416"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-020-00129-8"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00201"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2022.103312"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3190496"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2022.2026376"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9040282"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/separations10020107"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1618-6"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001939"},{"key":"e_1_2_12_14_2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/B978-0-12-802381-5.00037-3","volume-title":"Conn\u2019s Translational Neuroscience","author":"Prescott S. 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