{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:17:21Z","timestamp":1785233841415,"version":"3.55.0"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":187,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is a prevalent neurodegenerative disorder, while the existing treatments primarily focus on alleviating symptoms rather than addressing the underlying pathophysiology. Seeking a safer alternative, the study explores the potential of\n                    <jats:italic>Piper chaba<\/jats:italic>\n                    Hunter as a promising drug lead for AD by eliciting the major signaling pathway, key players, and their interaction with phytochemicals from the plant extract. Initially, the phytochemicals in the\n                    <jats:italic>P. chaba<\/jats:italic>\n                    crude extract were identified using GC\u2010MS, and their physicochemical properties were verified using SwissADME. Protein\u2013protein interaction (PPI) and signaling pathways\u2013target proteins\u2013compounds (STC) networks were analyzed to dig out target proteins and effective compounds for AD based on rigorous screening. Approximately 60 target proteins that interacted with GC\u2010MS\u2010identified compounds underwent PPI and STC networking which identified five compounds, a signaling pathway, and three target proteins with therapeutic potential. Three compounds, namely, bicyclo[7.2.0]undec\u20104\u2010ene, 4,11,11\u2010trimethyl\u20108\u2010methylene\u2010,[1R\u2010(1R\u2217,4Z,9S\u2217)], 2\u2010methoxybenzoic acid, 2,3\u2010dichlorophenyl ester, and (E)\u20103\u2010butylidene\u20104,5\u2010dihydroisobenzofuran\u20101(3H)\u2010one, have the potential to modulate PTGS2, PLA2G4A, and CYP2C19 within metabolic signaling pathway, thus serving as promising therapeutic agents. Moreover, the drug likeliness and efficacy of those phytochemicals were justified by molecular docking tests (MDTs), molecular dynamics simulations (MDSs), and quantum chemistry analyses, which confirmed their ability to inhibit key targets to mitigate AD\u2010associated pathology.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/8892801","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:23:21Z","timestamp":1751876601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling the Therapeutic Potential of\n                    <i>Piper chaba<\/i>\n                    Hunter: Computational Approaches Shed Light on Targeting Proteins in Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2025","author":[{"given":"Md. 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