{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:11:08Z","timestamp":1788952268756,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":251,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","award":["963492"],"award-info":[{"award-number":["963492"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder influenced by both environmental and genetic factors. MicroRNAs (miRNAs) are involved in the regulation of insulin signaling, inflammation, and pancreatic\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010cell function. Genetic polymorphisms in miRNA\u2010related regions may contribute to interindividual differences in T2DM susceptibility, although their functional effects remain uncertain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study is aimed at evaluating the association of five miRNA polymorphisms, miR\u2010499 rs3746444, miR\u201027a rs895819\/rs895519, miR\u201034a rs6577555, miR\u2010124a rs531564, and miR\u2010146a rs2910164, with susceptibility to T2DM in an Iranian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2013control study included 200 patients with T2DM and 202 unrelated healthy controls from southeastern Iran. Genotyping was performed using T\u2010ARMS\u2010PCR and PCR\u2010RFLP methods. Genotype and allele distributions were compared between groups, Hardy\u2013Weinberg equilibrium was assessed in controls, and crude odds ratios (ORs) were calculated under different genetic models. Multivariable logistic regression was also performed to estimate age\u2010 and sex\u2010adjusted ORs. Bonferroni correction was applied to account for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant associations with increased T2DM risk were observed for miR\u2010499 rs3746444 C allele (OR = 1.79, 95% CI\u2009=\u20091.34\u20132.39;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), miR\u201027a rs895819 G allele (OR = 1.89, 95% CI\u2009=\u20091.43\u20132.51;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and miR\u201034a rs6577555 A allele (OR = 2.91, 95% CI\u2009=\u20092.19\u20133.88;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). These associations remained evident in age\u2010 and sex\u2010adjusted codominant logistic regression models. In contrast, miR\u2010124a rs531564 and miR\u2010146a rs2910164 were not significantly associated with T2DM risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest that miR\u2010499 rs3746444, miR\u201027a rs895819\/rs895519, and miR\u201034a rs6577555 polymorphisms are associated with T2DM susceptibility in this Iranian population. However, these results indicate association rather than causation, and further large\u2010scale, multiethnic, and functional studies are needed to confirm their biological and clinical relevance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bmri\/8927160","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:19:01Z","timestamp":1788949141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of miR\u2010499, miR\u201027a, and miR\u201034a Gene Polymorphisms With Susceptibility to Type 2 Diabetes Mellitus in an Iranian Population: A Case\u2013Control Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3066-5164","authenticated-orcid":false,"given":"Mehrdad","family":"Behdani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2994-4243","authenticated-orcid":false,"given":"Mahmoud Ali","family":"Kaykhaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-2726","authenticated-orcid":false,"given":"Masoumeh","family":"Bahari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-4417","authenticated-orcid":false,"given":"Mohsen","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-4236","authenticated-orcid":false,"given":"Gholamreza","family":"Bahari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01655-5"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2022.18.34"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13567-6"},{"key":"e_1_2_13_4_2","volume-title":"IDF diabetes atlas","author":"Atlas I. 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