{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:01:46Z","timestamp":1789650106720,"version":"4.0.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":259,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The deposition of amyloid\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    (A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ) plaque is widely recognized as one of the core pathological events of Alzheimer\u2032s disease (AD). This study focused on uncovering potential diagnostic biomarkers and small\u2010molecule candidates potentially modulating A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010associated pathways in AD. Weighted gene coexpression network analysis (WGCNA) and machine learning identified the hub gene. Single\u2010nucleus RNA sequencing (snRNA\u2010seq) identified high\u2010expression cell clusters. We identified potential A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010binding small\u2010molecule candidates and calculated their binding affinities using molecular docking techniques. Based on molecular docking, we further evaluated the binding stability and conformational dynamics of the protein\u2013ligand complex through molecular dynamics (MD) simulations. NFKBIA was identified as a hub diagnostic gene. Three small molecules, resveratrol, curcumin, and apigenin, demonstrated strong binding affinities for NFKBIA. These findings clarify the priority candidate gene and feasible strategic directions, which are expected to be translated into practical pathways for precision diagnosis and treatment of AD.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/8975137","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:01:49Z","timestamp":1789646509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinformatics\u2010Driven Discovery of A\n                    <i>\u03b2<\/i>\n                    \u2010Targeted Therapeutics and Diagnostic Biomarkers for Alzheimer\u2032s 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