{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:25:42Z","timestamp":1791408342246,"version":"4.3.3"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019004","name":"Deanship of Research, Jordan University of Science and Technology","doi-asserted-by":"publisher","award":["20180475"],"award-info":[{"award-number":["20180475"]}],"id":[{"id":"10.13039\/501100019004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    is a troublesome bacterium that is highly prevalent in hospital settings, particularly in intensive care units (ICUs). Biofilm is one of the main virulence factors that makes\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    a successful pathogen, enabling it to survive the harshest environments. This study aimed to corrolate the biofilm\u2010forming capacity of clinical\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    isolates with their antibiotic resistance phenotypes and isolation sources. A total of 327 clinical isolates originated from different hospitals, were recovered from diverse clinical specimens collected from patients admitted to the ICU and non\u2010ICU wards. The isolates were characterized for their resistance phenotypes and biofilm formation capacities. Most\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    isolates showed high resistance patterns against all examined antibiotics. Based on the resistance profiles, 81.2% and 12.3% of isolates were classified into extensively resistant (XDR) and multidrug\u2010resistant (MDR), respectively. Moreover, the number of the ICU isolates exhibiting the XDR phenotype (86.7%) was higher than non\u2010ICU XDR isolates (76.4%). The biofilm\u2010forming capacity varied among the isolates, with most of the isolates forming either strong (44.3%) or weak biofilms (25.7%). Additionally, the fraction of ICU isolates with a strong capacity to form biofilms (60.7%, 91\/150) was higher compared with the non\u2010ICU isolates (30.5%, 54\/177). We found a significantly higher tendency to form biofilms in isolates that are susceptible to 10 out of the 17 antibiotics (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.014\u20130.002), including three carbapenems. In addition, a significant difference in the ability to form biofilms was revealed between the isolates originating from different hospitals and clinical specimens. Notably, a higher tendency to form biofilms was associated with susceptible strains isolated from blood (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.024\u20130.04) and cerebrospinal fluid (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001\u20130.009). Our findings indicate that investigating the biofilm formation capacity of clinical\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    strains could help identify patients requiring short or extended therapeutic treatments.\n                  <\/jats:p>","DOI":"10.1155\/bmri\/9348199","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:00:26Z","timestamp":1768572026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biofilm Formation in Clinical\n                    <i>Acinetobacter baumannii<\/i>\n                    Is Influenced by Isolate Source and Is Inversely Correlated With Antibiotic Resistance"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1561-1819","authenticated-orcid":false,"given":"Qutaiba","family":"Ababneh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dua\u2019a","family":"Alawneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-5778","authenticated-orcid":false,"given":"Ziad","family":"Jaradat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3093-2143","authenticated-orcid":false,"given":"Esra\u2019a","family":"Al-Zoubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-4253","authenticated-orcid":false,"given":"Ali","family":"Atoom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda\u2019a","family":"Aldaken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-9131","authenticated-orcid":false,"given":"Ekhlas","family":"Al-Rousan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazeed","family":"Alshari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8142-4072","authenticated-orcid":false,"given":"Ismail","family":"Saadoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1398388"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4572"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00055"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.10.004"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000337"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.a2016.0009"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00757-16"},{"key":"e_1_2_11_8_2","first-page":"119","article-title":"Biofilm Formation in Acinetobacter Baumannii","volume":"37","author":"Longo F.","year":"2014","journal-title":"New Microbiologica"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux010"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsec\/fiaa031"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9110817"},{"key":"e_1_2_11_12_2","first-page":"513","article-title":"Evaluation of Biofilm Production, Gelatinase Activity, and Mannose-Resistant Hemagglutination in Acinetobacter Baumannii Strains","volume":"41","author":"Cevahir N.","year":"2008","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05913-11"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2023-0263"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S169894"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/ijm\/1009049"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/17460913.2024.2412431"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-017-1283-1"},{"key":"e_1_2_11_19_2","first-page":"1","article-title":"Kirby-Bauer Disk Diffusion Susceptibility Test Protocol","volume":"15","author":"Hudzicki J.","year":"2009","journal-title":"American Society for Microbiology"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32066"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/ijm\/5749982"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7012(00)00122-6"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-365"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14998"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12071198"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0317798"},{"key":"e_1_2_11_28_2","first-page":"750","article-title":"Antimicrobial Susceptibility Patterns of Multidrug-Resistant Pseudomonas Aeruginosa and Acinetobacter Baumannii Against Carbapenems, Colistin, and Tigecycline","volume":"33","author":"Somily A. M.","year":"2012","journal-title":"Saudi Medical Journal"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/ijcp\/5516061"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.26719\/2015.21.11.828"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0111-2016"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.3126\/nje.v9i4.26962"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(01)00241-3"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13369-019-03893-9"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.01.010"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2014.0236"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.2436\/20.1501.01.270"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/jam.15795"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2021.09.001"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14709"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40550-022-00092-7"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2023.115278"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01916.x"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1179\/1973947813Y.0000000159"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00483"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.74315"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25661-9"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S228981"},{"key":"e_1_2_11_49_2","first-page":"2731","article-title":"The Correlation Between the Biofilm Formation Ability and the Drug Resistance of Acinetobacter Baumannii","volume":"13","author":"Yin Q.","year":"2020","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12739"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis939"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2014.09.007"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-014-0333-2"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0255-0857(21)01809-0"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.118416"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-47"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.8606"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2016.04.006"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24101849"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4272-0"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.3329\/jom.v14i1.14533"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.17795\/ajcmi-23954"},{"key":"e_1_2_11_63_2","doi-asserted-by":"crossref","DOI":"10.1186\/s13756-019-0612-5","article-title":"Study of Genetic Diversity, Biofilm Formation, and Detection of Carbapenemase, MBL, ESBL, and Tetracycline Resistance Genes in Multidrug-Resistant Acinetobacter Baumannii Isolated From Burn Wound Infections in Iran","volume":"8","author":"Ranjbar R.","year":"2019","journal-title":"Antimicrobial Resistance & Infection Control"},{"key":"e_1_2_11_64_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.9734\/ijpr\/2020\/v5i130124","article-title":"Evaluation of the Correlation Between Biofilm Formation and Drug Resistance in Clinical Isolates of Acinetobacter Baumannii","volume":"5","author":"Celik B.","year":"2020","journal-title":"International Journal of Pathogen Research"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S261939"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2016.02.002"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/9348199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bmri\/9348199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bmri\/9348199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:00:29Z","timestamp":1768572029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bmri\/9348199"}},"subtitle":[],"editor":[{"given":"Baisakhi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/bmri\/9348199"],"URL":"https:\/\/doi.org\/10.1155\/bmri\/9348199","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9348199"}}