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Despite advancements in medical treatment, current therapeutic strategies are often hindered by late\u2010stage diagnosis, high recurrence rates and resistance to therapies. These challenges highlight the urgent need for novel, less toxic and more effective treatment options. Phytoceuticals, bioactive plant\u2010derived compounds, have gained increasing attention for their potential to complement or enhance conventional cancer therapies. Among these, nobiletin, a polymethoxylated flavonoid found in citrus peels, has promising anti\u2010inflammatory, antioxidant and anticancer properties. This review explores the therapeutic potential of nobiletin in NSCLC, focusing on its ability to modulate key cancer hallmarks such as uncontrolled proliferation, metastasis, immune evasion and multidrug resistance. Preclinical studies suggest that nobiletin inhibits tumour growth, enhances chemosensitivity and suppresses metastasis through multiple pathways. 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