{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:59:31Z","timestamp":1772996371584,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":358,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the efficacy of sustained\u2010release fampridine tablets (fampridine\u2010SR) on walking impairment and fatigue on Chinese patients with multiple sclerosis (MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      All patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 12) had the baseline Expanded Disability Status Scale (EDSS) at 4\u20137 and orally administered fampridine\u2010SR at 10\u2009mg twice per day for at least 12\u2009weeks. All patients were assessed using EDSS, Timed 25\u2010Foot Walk (T25FW), the 12\u2010item Multiple Sclerosis Walking Scale (MSWS\u201012), and Modified Fatigue Impact Scale (MFIS) at baseline, day 1, week 1, 2, 4, 8, and 12.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The baseline EDSS score was 4.67\u2009\u00b1\u20090.36. Fampridine\u2010SR significantly decreased the EDSS score by 0.63\u2009\u00b1\u20090.20 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011) after 12\u2010week treatment. T25FW was changed at day 1 and week 1 by \u2212\u200912.73\u2009\u00b1\u20093.03% and \u2212\u200914.20\u2009\u00b1\u20094.36% (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.011), respectively. The statistically and clinically significant improvement of MSWS\u201012 was observed since week 1. The total, cognitive subscale, physical subscale, and psychosocial subscale of MFIS were significantly reduced in Chinese patients with MS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fampridine\u2010SR was a fast\u2010acting oral potassium channel blocker on improving walking ability of MS as early as day 1. It demonstrated the positive effects on walking impairment and fatigue, including the physical, cognitive, and psychosocial subscales of MFIS, in Chinese patients with MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bn\/6426255","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T01:52:38Z","timestamp":1766713958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Experience of Sustained\u2010Release Fampridine in Chinese Patients With Multiple Sclerosis: A Case Series on Walking Impairment and 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