{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:59:14Z","timestamp":1772996354073,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009533","name":"Armenian National Science and Education Fund","doi-asserted-by":"publisher","award":["23AN:NS-biochem-2925"],"award-info":[{"award-number":["23AN:NS-biochem-2925"]}],"id":[{"id":"10.13039\/100009533","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:italic>Sutherlandia frutescens<\/jats:italic>\n                    (\n                    <jats:italic>SF<\/jats:italic>\n                    ) is a plant used traditionally in South Africa for various health conditions, including neurological disorders. Parkinson\u2019s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra, resulting in motor symptoms. Rotenone, a pesticide, has been linked to PD\u2010like symptoms in both in vitro and in vivo studies. However,\n                    <jats:italic>SF<\/jats:italic>\n                    \u2010specific effects of\n                    <jats:italic>SF<\/jats:italic>\n                    on PD\u2010related symptoms have not been extensively studied. This study was aimed at investigating the potential neuroprotective effects of\n                    <jats:italic>SF<\/jats:italic>\n                    against rotenone\u2010induced PD using in vivo electrophysiological recordings from the hippocampus and an open\u2010field test to assess motor behavior. Rats were divided into three groups: a control group receiving sunflower oil, a rotenone group treated with rotenone (2.0\u2009mg\/kg), and an\n                    <jats:italic>SF<\/jats:italic>\n                    group treated with hydroponically grown\n                    <jats:italic>SF<\/jats:italic>\n                    extract. Electrophysiological recordings from the hippocampus were conducted to assess neuronal activity, and an open\u2010field test was used to evaluate motor behavior. Rats treated with\n                    <jats:italic>SF<\/jats:italic>\n                    exhibited significantly higher motor activity compared to both the sunflower oil and rotenone groups, suggesting an activating effect of\n                    <jats:italic>SF<\/jats:italic>\n                    on motor behavior. In contrast, the rotenone group displayed reduced activity levels and exploratory behavior, highlighting the suppressive impact of rotenone on motor function. These findings suggest that\n                    <jats:italic>SF<\/jats:italic>\n                    modulates hippocampal neuronal activity and may offer neuroprotective benefits against rotenone\u2010induced PD\u2010like symptoms.\n                    <jats:italic>SF<\/jats:italic>\n                    , a plant with traditional medicinal applications, shows potential in modulating motor behavior and hippocampal neuronal activity in a rotenone\u2010induced PD model. Further studies are needed to clarify the underlying mechanisms and evaluate the clinical relevance of\n                    <jats:italic>SF<\/jats:italic>\n                    in PD management.\n                  <\/jats:p>","DOI":"10.1155\/bn\/6606560","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:14:41Z","timestamp":1741716881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Neuroprotective Potential of\n                    <i>Sutherlandia frutescens<\/i>\n                    in a Rotenone\u2010Induced Rat Model of Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5364-2838","authenticated-orcid":false,"given":"Lilit","family":"Darbinyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-6545","authenticated-orcid":false,"given":"Karen","family":"Simonyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7605-5189","authenticated-orcid":false,"given":"Larisa","family":"Manukyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-3219","authenticated-orcid":false,"given":"Vaghinak","family":"Sarkisian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-1180","authenticated-orcid":false,"given":"Lusya","family":"Hovhannisyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3694-4068","authenticated-orcid":false,"given":"Lilia","family":"Hambardzumyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.11.002"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2004.1.145"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.07.012"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.07.054"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v8i4.14"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089748"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041061"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.11.012"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759091414554946"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-016-8402-1"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-223363"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2022.06.002"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00561-6"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010498"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10444"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202465"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000526377"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.13275"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00993"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.37349\/ent.2023.00036"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02056.x"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1335550"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00175"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113226"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.41302"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.07.038"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0045168"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1042\/NS20210026"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.15586\/codonpublications.parkinsonsdisease.2018"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.3.353"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3528"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00180-8"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01426.x"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep45465"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602740200"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.02.003"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70118-2"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.nrl.0000131146.08278.a5"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370213510253"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2007.08.002"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-4-19"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160994"},{"key":"e_1_2_10_44_2","volume-title":"The rat brain in stereotaxic coordinates: compact","author":"Paxinos G.","year":"2005"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2017.01.001"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-017-0060-y"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.00145"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00233"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01272-X"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.04.012"}],"container-title":["Behavioural Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bn\/6606560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bn\/6606560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bn\/6606560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:59:37Z","timestamp":1772985577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bn\/6606560"}},"subtitle":[],"editor":[{"given":"Enzo","family":"Emanuele","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/bn\/6606560"],"URL":"https:\/\/doi.org\/10.1155\/bn\/6606560","archive":["Portico"],"relation":{},"ISSN":["0953-4180","1875-8584"],"issn-type":[{"value":"0953-4180","type":"print"},{"value":"1875-8584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6606560"}}