{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T05:01:50Z","timestamp":1779858110563,"version":"3.53.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":145,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-EURE-0017 grant"],"award-info":[{"award-number":["ANR-17-EURE-0017 grant"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Annonaceae fruits such as soursop (\n                      <jats:italic>Annona muricata<\/jats:italic>\n                      ) may worsen symptoms of Parkinson\u2032s disease (PD) in tropical regions. Here, we investigate whether PD is more severe in an Annonaceae\u2010exposed compared with a nonexposed population. Motor and cognitive symptoms of two PD groups (Caribbean,\n                      <jats:italic>N<\/jats:italic>\n                      = 74; mainland France,\n                      <jats:italic>N<\/jats:italic>\n                      = 104) were compared after imputation, propensity matching, and multivariate adjustment according to age, disease duration, education, and dopaminergic therapy. Ninety\u2010six percent of Caribbean (71\/74) but none of interviewed mainland France (0\/20) PD patients had been exposed to Annonaceae fruits. Caribbean PD patients exhibited more severe motor and cognitive symptoms than mainland France PD patients (Unified\u2009PD\u2009Rating\u2009Scale \u2212 3 = 24.39 [\u00b1\u200914.06] vs. 18.50 [\u00b1\u200911.13],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001; Mattis\u2009Dementia\u2009Rating\u2009Scale = 127.21 [\u00b114.30] vs. 130.80 [\u00b1\u200911.15],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005). Given the growing evidence supporting Annonaceae fruits toxicity, health policy makers should raise public awareness about the risks of such consumption.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT03368300<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/bn\/8897550","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T04:03:02Z","timestamp":1779854582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Clinical Effect of Annonaceae Fruit Consumption on Caribbean Parkinson\u2032s Disease Severity"],"prefix":"10.1155","volume":"2026","author":[{"given":"Louis","family":"Ribeyron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9e","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gine","family":"Edragas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Belson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Tressi\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-2210","authenticated-orcid":false,"given":"Anne-Catherine","family":"Bachoud-L\u00e9vi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Remy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Roze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-4641","authenticated-orcid":false,"given":"Laurent","family":"Cleret 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Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bn\/8897550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/bn\/8897550","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/bn\/8897550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T04:03:04Z","timestamp":1779854584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/bn\/8897550"}},"subtitle":[],"editor":[{"given":"Nikhat","family":"Kaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/bn\/8897550"],"URL":"https:\/\/doi.org\/10.1155\/bn\/8897550","archive":["Portico"],"relation":{},"ISSN":["0953-4180","1875-8584"],"issn-type":[{"value":"0953-4180","type":"print"},{"value":"1875-8584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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