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This review summarizes (i) chemerin biosynthesis, processing, receptors, and signaling (CMKLR1\/ChemR23, GPR1, and CCRL2), (ii) key physiological roles in immune cell trafficking, adipogenesis, glucose and lipid homeostasis, and vascular biology, and (iii) current evidence linking chemerin signaling to major metabolic disorders and selected nonmetabolic diseases. Overall, circulating chemerin is frequently elevated in obesity, insulin resistance, metabolic syndrome, Type 2 diabetes, nonalcoholic fatty liver disease, and hypertension and often correlates with inflammatory markers; however, heterogeneity in study design, confounding, and limited isoform\u2010specific measurements complicate causal inference and diagnostic validation. Beyond metabolism, chemerin signaling has been implicated in inflammatory conditions (e.g., rheumatoid arthritis and psoriasis) and multiple cancers with tumor type\u2013specific pro\u2010 or antitumor effects. Standardized assays, isoform\u2010resolved measurements, and prospective studies are needed to clarify disease mechanisms and determine the clinical utility of chemerin as a biomarker or target.<\/jats:p>","DOI":"10.1155\/bri\/1761697","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:10:49Z","timestamp":1783419049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chemerin Normal Function and Roles in Metabolic and Nonmetabolic Disorders: An Up\u2010To\u2010Date Comprehensive Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-0933","authenticated-orcid":false,"given":"Noha A.","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-9086","authenticated-orcid":false,"given":"Aida A.","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-034X","authenticated-orcid":false,"given":"Rehab G.","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-4327","authenticated-orcid":false,"given":"Nour Y. 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