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It survives and proliferates in macrophage autophagosomes, gastric epithelial cells, and dendritic cells, with its cytotoxin\u2010associated gene A (\n                    <jats:italic>CagA<\/jats:italic>\n                    ) and vacuolating Toxin A (\n                    <jats:italic>VacA<\/jats:italic>\n                    ) interfering with autophagy. While most infected patients develop chronic gastritis, 10%\u201315% develop ulcers, and 1%\u20133% progress to GC. MicroRNAs (miRNAs), small noncoding RNAs, regulate genes by modulating tumor suppressors and oncogenes, and are crucial in GC. This review explores miRNAs as potential biomarkers and therapeutic targets for early GC diagnosis, monitoring progression, and predicting treatment outcomes. Dysregulated miRNAs such as miR\u2010124, miR\u2010145, and miR\u201021 have been identified in GC. 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