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With rising antibiotic resistance, there is a pressing need to discover alternative QS inhibitors (QSIs) targeting SdiA. This study evaluated 239 phytochemicals from\n                    <jats:italic>Daniellia oliveri<\/jats:italic>\n                    as potential SdiA modulators using in silico techniques. Virtual screening identified four lead compounds (cadala\u20101(10),3,8\u2010triene, carotenoid K, valencene, and \u03b2\u2010sesquiphellandrene), with carotenoid K (\u221253.71\u2009kcal\/mol) exhibiting a higher binding free energy compared to the standard, azithromycin (\u221252.19\u2009kcal\/mol), following dynamics simulation. Notably, the SdiA\u2010carotenoid K complex demonstrated enhanced thermodynamic stability with a root mean square deviation (RMSD) of 2.64\u2009\u00c5. All four leads, except carotenoid K, conformed to the Lipinski rule for selection of candidates that could be administered orally. Quantum chemical feature analyses using DFT\/B3LYP showed that carotenoid K had the lowest HOMO\u2010LUMO energy gap, high ionization energy, and electrophilicity index values, indicating its superior reactivity and stability. These properties suggest enhanced interactions with the SdiA active site compared to other investigated compounds. These observations highlight carotenoid K as a promising modulator of SdiA. However, further structural modification and validation through\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    studies are recommended.\n                  <\/jats:p>","DOI":"10.1155\/bri\/7191508","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T01:49:08Z","timestamp":1749520148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>In Silico<\/i>\n                    Bioprospection of\n                    <i>Daniellia oliveri\u2013<\/i>\n                    Based Products as Quorum Sensing Modulators of\n                    <i>Escherichia coli<\/i>\n                    SdiA"],"prefix":"10.1155","volume":"2025","author":[{"given":"Yamkela","family":"Dweba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-8968","authenticated-orcid":false,"given":"Christiana","family":"Eleojo Aruwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-9220","authenticated-orcid":false,"given":"Saheed","family":"Sabiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035988"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjm.2016.10.015"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261444"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.25258\/ijddt.10.2.1"},{"key":"e_1_2_10_5_2","article-title":"Phylogenetic Analysis and Antibiotic Resistance of Escherichia coli Isolated From Wild and Domestic Animals at an Agricultural land Interface Area of Salaphra Wildlife Sanctuary, Thailand","volume":"15","author":"Duangurai T.","year":"2022","journal-title":"Veterinary World"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.5455\/javar.2022.i584"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1179\/2047773215y.0000000001"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.07.012"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01128-06"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012427"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01100"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781003300557-3"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02585.x"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.01.006"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12139"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/s120404661"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2020.100695"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249253"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051068"},{"key":"e_1_2_10_20_2","article-title":"Phytomedicines","author":"Van Wyk B. 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