{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:18:50Z","timestamp":1786115930790,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":216,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100078"],"award-info":[{"award-number":["82100078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2025AHGXZK31456"],"award-info":[{"award-number":["2025AHGXZK31456"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2023AH030117"],"award-info":[{"award-number":["2023AH030117"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017668","name":"Anhui Provincial Key Research and Development Plan","doi-asserted-by":"publisher","award":["2022i01020003"],"award-info":[{"award-number":["2022i01020003"]}],"id":[{"id":"10.13039\/501100017668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Cellular stress is implicated in the progression of lipopolysaccharide (LPS)\u2010evoked acute lung injury (ALI). The goal of this study was to evaluate the effect of oral supplementation with rosiglitazone (RSG), which is an agonist of peroxisome proliferator\u2010activated receptor (PPAR)\u2010\u03b3, on pulmonary inflammatory response, oxidative stress, and endoplasmic reticulum (ER) stress during LPS\u2010evoked ALI in mice. The mice were randomly divided into four groups and orally supplemented with or without RSG (10\u2009mg\/kg) once daily for 5 consecutive days before LPS (1\u2009mg\/kg) intraperitoneal injection. The mice were sacrificed at 12\u2009h after LPS injection. As expected, LPS\u2010evoked ALI and death were attenuated in mice that were pretreated with RSG. LPS\u2010evoked increase in chemokines (KC, MIP\u20102, and MCP\u20101) and proinflammatory cytokines (TNF\u2010\u03b1 and IL\u20101\u03b2) was inhibited in the mouse lungs by RSG. RSG pretreatment significantly mitigated LPS\u2010evoked nuclear translocation of NF\u2010\u03baB p65 and p50, which regulate inflammatory gene transcription in the lungs. Additionally, LPS\u2010evoked glutathione depletion and lipid peroxidation were alleviated by RSG. The abnormal expression of NADPH oxidases and antioxidant enzymes was restored in the lung tissues by RSG. Further experiments revealed that LPS\u2010evoked upregulation of GRP78,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010IRE1\u03b1, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010EIF2\u03b1 was blocked by RSG pretreatment. Mechanistically, RSG pretreatment enhanced PPAR\u03b3 activity in the mouse lungs and bronchial epithelial cells. RSG promoted the interaction between NF\u2010\u03baB p65 and PPAR\u03b3 in the mouse lungs. Overall, RSG pretreatment protects against LPS\u2010evoked ALI partially through enhancing PPAR\u03b3 activity and inhibiting the cellular stress response in the mouse lungs.\n                  <\/jats:p>","DOI":"10.1155\/carj\/1600008","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T06:15:48Z","timestamp":1785996948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Rosiglitazone Supplementation Mitigates Pulmonary Cellular Stress Response During Lipopolysaccharide\u2010Evoked Acute Lung Injury in Mice"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5407-8254","authenticated-orcid":false,"given":"Jun-Ping","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3528-0132","authenticated-orcid":false,"given":"Wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2140-3517","authenticated-orcid":false,"given":"Zhao-Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4155-9633","authenticated-orcid":false,"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0243-6986","authenticated-orcid":false,"given":"Zhen-Zhen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2759-8201","authenticated-orcid":false,"given":"Xiu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6621-1524","authenticated-orcid":false,"given":"Jia-Le","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9688-8133","authenticated-orcid":false,"given":"Min-Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9919-2888","authenticated-orcid":false,"given":"Dong-Xu","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-3560","authenticated-orcid":false,"given":"Lin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7588-0588","authenticated-orcid":false,"given":"Jun","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8100-1146","authenticated-orcid":false,"given":"Ling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00439-6"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14728214.2019.1591369"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2020.09.001"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01485-4"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2479-y"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050333"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2010.12.005"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.5.1303"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.01.052"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-022-00318-8"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.01.045"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114713"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.11.005"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154338"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0230"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10839-0"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00187812"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3181659932"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.01.004"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117134"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112164"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-15914-y"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900229"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000964"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900132"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113595"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01637-4"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.11.012"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-009-9161-z"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.020"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.679106"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03034-3"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061742"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04227-0"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0366-y"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18298-2"},{"key":"e_1_2_14_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.10.381"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.07.046"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S348850"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000617"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02745-1"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.12.008"},{"key":"e_1_2_14_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2052-6"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104649"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002121"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.02.023"},{"key":"e_1_2_14_48_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11300"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.02.013"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109088"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00202"}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carj\/1600008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carj\/1600008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carj\/1600008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T06:15:50Z","timestamp":1785996950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carj\/1600008"}},"subtitle":[],"editor":[{"given":"Lipi","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/carj\/1600008"],"URL":"https:\/\/doi.org\/10.1155\/carj\/1600008","archive":["Portico"],"relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"value":"1198-2241","type":"print"},{"value":"1916-7245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1600008"}}