{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:26:55Z","timestamp":1787293615302,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":231,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a lack of evidence related to weaning noninvasive ventilation in bronchiolitis. The purpose of this study was to identify variables related to NIV weaning readiness and approach in bronchiolitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of 74 children less than two years of age with bronchiolitis, requiring NIV and admitted to a pediatric intensive care unit (PICU) from 2022 to 2023. Demographic variables, clinical metrics, NIV mode, and weaning metrics were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean total duration of NIV therapy was 40\u2009h with weans lasting 13\u2009h. Duration for children on CPAP alone was shorter (26\u2009h) than for children on combination of BiPAP and CPAP (45\u2009h, 95% CI 4.258 to 33.742,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0123). Wean times were also shorter for children on CPAP alone (mean 5\u2009h) than children on BiPAP and CPAP (mean 16\u2009h) (95% CI 1.899 to 20.101,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0185). Patients were more likely to have a \u201ccomplex wean,\u201d defined as escalation and de\u2010escalation between multiple settings, with BiPAP (44.6%) than with CPAP (18.8%). RR at first wean was a significant predictor of NIV weaning duration (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a need for NIV weaning guidelines. RR may be an important predictor of NIV weaning readiness and approach. A \u201ccomplex wean\u201d may be a potential outcome variable for weaning NIV in children with bronchiolitis. This study may be used to inform future research and guidelines for weaning NIV in children with bronchiolitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/carj\/2042835","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:22:07Z","timestamp":1787293327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Noninvasive Ventilation in Pediatric Bronchiolitis: Variables Related to Weaning Readiness and Approach"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-9243","authenticated-orcid":false,"given":"Rheanna","family":"Bulten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-714X","authenticated-orcid":false,"given":"Gregory","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-0680","authenticated-orcid":false,"given":"Tanya","family":"Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2092"},{"key":"e_1_2_11_2_2","first-page":"742","article-title":"Bronchiolitis","volume":"54","author":"Worrall G.","year":"2008","journal-title":"Canadian Family Physician"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.10746"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003139"},{"key":"e_1_2_11_5_2","first-page":"30324","article-title":"Continuous Positive Airway Pressure Vs. High Flow Nasal Cannula in Children With Acute Severe or Moderate Bronchiolitis: A Systematic Review and Meta-Analysis","volume":"0210","author":"Catan\u0303o-Jaramillo M. L.","year":"2020","journal-title":"Medicina Intensiva (English Edition)"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmaa128"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet070"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2023.03.003"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.71108"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24890"},{"key":"e_1_2_11_11_2","article-title":"Severity Scoring Used in Assessment of Bronchiolitis: A Systematic Review","volume":"58","author":"Bedson W.","year":"2021","journal-title":"European Respiratory Journal"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2024.08.006"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13908-6"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26753"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066620979642"},{"key":"e_1_2_11_16_2","article-title":"Non-Invasive Ventilation in Pediatric Bronchiolitis: Variables Related to Weaning Readiness and Efficacy","author":"Bulten R.","year":"2025","journal-title":"Authorea"}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carj\/2042835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carj\/2042835","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carj\/2042835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:22:09Z","timestamp":1787293329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carj\/2042835"}},"subtitle":[],"editor":[{"given":"Awni M","family":"Al-Subu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/carj\/2042835"],"URL":"https:\/\/doi.org\/10.1155\/carj\/2042835","archive":["Portico"],"relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"value":"1198-2241","type":"print"},{"value":"1916-7245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2042835"}}