{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:46:19Z","timestamp":1791798379240,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":284,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) are strongly linked to pulmonary hypertension and left ventricular abnormalities, driving cardiovascular issues. OHS, with daytime hypercapnia, affects 10%\u201320% of OSA patients. Continuous positive airway pressure (CPAP) is the first\u2010line therapy, but its cardiac effects are inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis adhering to the PRISMA 2020 statement. Risk of bias was assessed using RoB 2 (RCTs) and the Newcastle\u2013Ottawa Scale (NOS; cohort studies). Continuous outcomes were pooled as mean differences (MDs) with 95% CIs using random\u2010effects models (restricted maximum likelihood) with Hartung\u2013Knapp adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight studies (574 participants; 2 RCTs, 6 cohorts) were included, showing that CPAP significantly reduced pulmonary arterial pressure (MD\u2009=\u2009\u22122.32\u2009mmHg, 95% CI: \u22123.88 to \u22120.76,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) versus controls. Secondary analyses indicated improved left ventricular diastolic function (early\u2010to\u2010late diastolic mitral inflow velocity [E\/A] ratio: MD\u2009=\u20090.29, 95% CI: 0.09 to 0.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). No significant effects on left ventricular mass index (LVMi) (MD\u2009=\u2009\u22122.31 percentage points, 95% CI: \u22126.38 to 1.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.27) or left ventricular ejection fraction (LVEF) (MD\u2009=\u20090.53 percentage points, 95% CI: \u22121.49 to 2.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.61) were found. Sensitivity analyses confirmed robustness. Funnel plot analysis suggested potential publication bias for pulmonary artery systolic pressure (PASP)\/mean pulmonary artery pressure (mPAP), E\/A ratio, and LVEF, while LVMi showed low bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In adults with OSA or OHS, CPAP reduces pulmonary arterial pressure and improves LV diastolic function, but it does not significantly alter LVMi or ejection fraction. These findings support CPAP as a key intervention to mitigate pulmonary hemodynamic burden and diastolic dysfunction in this high\u2010risk population, while its potential to reverse structural cardiac remodeling requires further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/carj\/3020878","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:59:27Z","timestamp":1791795567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous Positive Airway Pressure Effects on Pulmonary Hemodynamics and Left Ventricular Function in Obstructive Sleep Apnea and Obesity Hypoventilation Syndrome: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9612-9664","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep 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Respiratory and Sleep Medicine Hebei Medical University Third Hospital  Shijiazhuang 050051 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Hebei Medical University Third Hospital  Shijiazhuang 050051 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Hebei Medical University Third Hospital  Shijiazhuang 050051 Hebei 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