{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:05:07Z","timestamp":1785153907689,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":207,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD) are among the leading chronic diseases that significantly impact global morbidity and mortality. Growing evidence indicates a bidirectional interplay between metabolic and pulmonary dysfunction. This study aims to identify the demographic and regional trends of DM and COPD\u2010related mortality in the United States from 2000 to 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>DM\u2010 and COPD\u2010related deaths in the United States from 2000 to 2023 were obtained from the CDC WONDER database using ICD\u201010 code E10\u201014 for DM and J40\u201044 as the underlying cause of death. Results are presented as age\u2010adjusted mortality rates (AAMR) per 100,000 population, with Joinpoint regression used for trend analysis and to calculate annual percentage change (APC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 796,757 DM\u2010 and COPD\u2010related deaths were recorded. From 2000 to 2008, the AAMR for DM and COPD increased from 11.19 to 14.32, remaining relatively stable until 2018. This was followed by a significant rise to 19.03 in 2021 (APC: 10.57), before declining to 16.28 in 2023 (APC: \u22129.08). Men demonstrated a higher AAMR (19.28) than women (12.02); however, both experienced decline post\u20102021, with rates falling to 20.54 in men (APC: \u22129.08) and 13.02 in women (APC: \u22128.33). AAMR increased among all racial groups except Asians and Hispanics. From 2000 to 2021, American Indians had the highest AAMR (30.48). After 2021, AAMR declined across all groups. Rural areas reported higher AAMR (19.02), compared to urban areas (12.85). AAMR in rural areas increased markedly from 2018 to 2020 (13.67). State\u2010level comparisons revealed substantial variation in AAMR. Oklahoma had the highest rate at 28.79, followed by West Virginia (28.53), Kentucky (26.74), Vermont (23.95), and Mississippi (20.83). In contrast, Hawaii (6.69), Utah (7.33), and Massachusetts (7.99) reported the lowest rates, all below 10. Regionally, the Midwest had the highest average AAMR (16.30).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>COPD\u2010related diabetes mortality rose from 2000 to 2020, highest among men, Non\u2010Hispanic American Indians, and rural populations, and then declined post\u20102021. Findings indicate increased vulnerability during acute events, highlighting the need for targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/carj\/3655829","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:28:47Z","timestamp":1785151727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mortality Trends in Patients Aged 25 and Older With Comorbid COPD and Diabetes Mellitus in the United States: A CDC WONDER Database Study From 2000 to 2023"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5578-2022","authenticated-orcid":false,"given":"Muhammad","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5448-3382","authenticated-orcid":false,"given":"Saba","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1587-4320","authenticated-orcid":false,"given":"Shaheer Bin","family":"Shafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6019-9842","authenticated-orcid":false,"given":"Khubaib Tariq","family":"Mansoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Aqsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9230-6569","authenticated-orcid":false,"given":"Muhammad Abdullah","family":"Naveed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1176-7928","authenticated-orcid":false,"given":"Ahila","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-6651","authenticated-orcid":false,"given":"Harigopal","family":"Sandhyavenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8328-9925","authenticated-orcid":false,"given":"Binish","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8182-1260","authenticated-orcid":false,"given":"Sivaram","family":"Neppala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_12_1_2","first-page":"1","volume-title":"IDF DIABETES ATLAS","author":"Magliano D. 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