{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:48:19Z","timestamp":1782715699177,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":178,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study primarily analyzed differences in venous thromboembolism (VTE) characteristics across altitudes and their temporal trends during the puerperium. Additionally, it identified independent risk factors for postpartum pulmonary embolism (PE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study reviewed all postpartum VTE cases at People\u2019s Hospital of Xizang Autonomous Region between 2015 and 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This cohort study of 172 postpartum women (median age 31 [IQR 26\u201336]) compared high\u2010altitude (HA,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009109) and very high\u2010altitude (VHA,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200963) groups. PE proportion was significantly higher in VHA vs. HA\n                      <jats:italic>(<\/jats:italic>\n                      <jats:italic>p<\/jats:italic>\n                      = 0.033). VHA subjects also showed significant elevated preterm delivery (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.033) and \u2265\u20093 deliveries (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Joinpoint regression (2015\u20132024) revealed biphasic trends: significant early\u2010phase escalations in VTE (APC\u2009=\u200918.05%) and deep vein thrombosis (DVT) (APC\u2009=\u200919.66%) during 2015\u20132022 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), followed by clinically relevant (though statistically nonsignificant) late\u2010phase reductions. PE proportion demonstrated a significant overall increase (APC\u2009=\u200918.77%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In multivariate analysis, four independent predictors significantly increased PE risk: altitude gradient (OR 1.035,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), multiparity (OR 2.548,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004), hypertension or eclampsia (OR 1.797,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001), and structural heart disease (OR 1.988,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This decade\u2010long analysis (2015\u20132024) revealed significant altitudinal gradients in postpartum VTE. Clinically significant escalation of postpartum VTE burden in high\u2010altitude populations warrants urgent intervention. Integrated multiparity management and enhanced comorbidity control are critical future initiatives for resolving key perinatal thrombotic risk bottlenecks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/carj\/3703610","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:35:04Z","timestamp":1782714904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postpartum Venous Thromboembolism: Altitudinal Gradients, Decadal Trends, and PE\u2010Specific Risk Profiling in Highland Populations"],"prefix":"10.1155","volume":"2026","author":[{"given":"Jianbo","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lobsang","family":"Chodron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenzin","family":"Chodron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u2019nga","family":"Cering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiliang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-e","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0947-6402","authenticated-orcid":false,"given":"Zhenzhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7703-6024","authenticated-orcid":false,"given":"Lobsang","family":"Cering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7841-2863","authenticated-orcid":false,"given":"Guiying","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2022.100754"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12290"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2018.04.007"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620914222"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2021.05.019"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.008815"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01622.x"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.18229"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.12.013"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1769736"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070310"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S404537"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21105"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450121666200422084414"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-024-00643-2"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2019.0049"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301413"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1453700"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2022.0154"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657770"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH17-02-0138"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.1946265"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.12780"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024802"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2023.05.013"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn115791-20240702-00348"},{"key":"e_1_2_13_27_2","first-page":"1538","volume-title":"Bulletin of the State Council of the People\u2019s Republic of China","author":"Implementation Measures for Subsidies for Difficult and Remote Areas of Government Agencies and Institutions","year":"1993"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-025-07246-3"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2024.102446"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14776"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.929904"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/10760296221076148"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03863-w"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-025-08570-4"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112141-20200414-00326"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112137-20220903-01866"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980008002401"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14093"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00275.2009"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000001074"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000046327"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.10.004"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2448-7"}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carj\/3703610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carj\/3703610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carj\/3703610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:35:07Z","timestamp":1782714907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carj\/3703610"}},"subtitle":[],"editor":[{"given":"Sami","family":"Deniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/carj\/3703610"],"URL":"https:\/\/doi.org\/10.1155\/carj\/3703610","archive":["Portico"],"relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"value":"1198-2241","type":"print"},{"value":"1916-7245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3703610"}}