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Unlike low\u2010altitude PE, high\u2010altitude pulmonary embolism (HA\u2010PE) may result from unique hypoxia\u2010driven mechanisms, including hemoconcentration, endothelial dysfunction, and a hypercoagulable state. In this narrative review, we summarize current evidence on the epidemiology, pathophysiology, diagnosis, management, and prognosis of HA\u2010PE, based on the literature published between 2010 and 2025 retrieved from PubMed and CNKI. This review summarizes the epidemiological profile, clinical features, altitude\u2010related diagnostic challenges, limitations of current therapeutic strategies, and the prognosis of HA\u2010PE. 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