{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:03:32Z","timestamp":1785251012728,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":208,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies that investigate the use of high\u2010frequency percussive ventilation (HFPV) are scarce and outdated. HFPV is being used in some facilities primarily as a salvage modality on patients with acute respiratory distress syndrome (ARDS) when a conventional mechanical ventilator has failed to improve outcomes. There still are arguments whether HFPV is an effective ventilation strategy for adult patients with ARDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this study was to analyze and compare pulmonary gas exchange, as measured by arterial blood gas (ABG) values, between patients with ARDS who were transitioned from conventional mechanical ventilation to HFPV and those who remained on conventional mechanical ventilation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study between 2016 and 2022. Data was extracted and analyzed from electronic medical records (EMRs) of ARDS patients. ABG results were analyzed from 12 to 2\u2009h before, and 30\u2009min, 2, 12, and 24\u2009h after the initiation of conventional and HFPV. Continuous mandatory ventilation (CMV) settings were compared over 12 and 2\u2009h before the initiation of HFPV and 2, 12, and 24\u2009h after.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      A total of\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009351 cases were evaluated for this study (\n                      <jats:italic>n<\/jats:italic>\n                      1\u2009=\u2009194 in the CMV group and\n                      <jats:italic>n<\/jats:italic>\n                      2\u2009=\u2009157 in the HFPV group). Patients in the HFPV group had a lower mean baseline pH (7.25 vs. 7.34,\n                      <jats:italic>p<\/jats:italic>\n                      = &lt;0.001) and higher PaCO\n                      <jats:sub>2<\/jats:sub>\n                      (56.7 vs. 40.3\u2009mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      = &lt;0.001) when compared to the CMV group. pH has increased and PaCO\n                      <jats:sub>2<\/jats:sub>\n                      decreased quickly once HFPV was initiated. The mean baseline PaO\n                      <jats:sub>2<\/jats:sub>\n                      was comparative (61.7 vs. 67.4\u2009mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.21) but the HFPV group had a more rapid and higher improvement compared to the CMV group (121.5 vs. 86.6,\n                      <jats:italic>p<\/jats:italic>\n                      = &lt;0.001). Similarly, there was a significant improvement in the PF ratio after 12\u2009h on HFPV (160.7 vs. 139.7,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results show that HFPV can effectively be used for adult ARDS as a salvage modality when a patient\u2019s ABG has become refractory to conventional mechanical ventilation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/carj\/5796675","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:56:21Z","timestamp":1785250581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Respiratory Distress Syndrome: Mechanical Ventilation vs. High\u2010Frequency Percussive Ventilation"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6809-8988","authenticated-orcid":false,"given":"Daniel","family":"Sagan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-6160","authenticated-orcid":false,"given":"Carol","family":"Parise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehreen","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7844-8943","authenticated-orcid":false,"given":"Abdullah","family":"Alismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s334043"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.08.013"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.12.019"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21907"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.12007"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202311-2011st"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217405"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003-0655cp"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1532ci"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.09.042"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/cce.0000000000000452"},{"key":"e_1_2_12_13_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.chest.2021.11.022","article-title":"Fibrinolytics as an ARDS Salvage Option: Promising, but ARDS Prevention Options are Needed Urgently","volume":"161","author":"Cap A. 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