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A deeper understanding of its mechanisms of action could aid in the development of novel treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We established an IPF mouse model by administering bleomycin (BLM), followed by treatment with YFT. Histopathological analysis of lung tissue was conducted to evaluate the effects of YFT, along with transcriptomic profiling to identify key regulatory molecules involved in its therapeutic action. Immunofluorescence staining was performed for TRKA and surfactant protein C (SP\u2010C) in IPF lung slices. A549 cells were induced with TGF\u2010\u03b21 to assess the effect of YFT on alveolar epithelial cells, and cells overexpressing TRKA were constructed. Western blotting analysis was performed to detect EMT\u2010 and PI3K\/AKT pathway\u2010related protein levels, and an EdU proliferation assay was conducted to measure the proliferation of A549\u2009cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      YFT intervention reduced pathological lung injury in BLM\u2010treated mice. GO enrichment analysis revealed enrichment of DEGs in the extracellular matrix and proteinaceous extracellular matrix. Analysis of the enriched KEGG pathways revealed enrichment of the PI3K\u2013AKT signaling pathway. YFT also decreased the number of SP\u2010C\n                      <jats:sup>+<\/jats:sup>\n                      \/TRKA\n                      <jats:sup>+<\/jats:sup>\n                      cells in lung tissues, inhibited the expression of TRKA, and reduced the NGF concentration in TGF\u2010\u03b21\u2010stimulated A549\u2009cells. YFT reduced TRKA, PI3K, and AKT phosphorylation levels, EMT, and cell proliferation. However, these effects were eliminated when TRKA was overexpressed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>YFT might regulate the NGF\/TRKA\/PI3K\/AKT pathway to alleviate pulmonary fibrosis by reducing EMT and cell proliferation. This study laid the groundwork for future research on the possible enhancement of the therapeutic effect of YFT when YFT is combined with other medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/carj\/6614209","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:08:11Z","timestamp":1769760491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Yifei Decoction Regulates the NGF\/TRKA\/PI3K\/AKT Signaling Axis to Inhibit the Epithelial\u2013Mesenchymal Transformation and Proliferation of Pulmonary Epithelial Cells in Bleomycin\u2010Induced Pulmonary Fibrogenesis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2780-196X","authenticated-orcid":false,"given":"Lijuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5564-2236","authenticated-orcid":false,"given":"Chengzhong","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9981-7142","authenticated-orcid":false,"given":"Xiangli","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1973-9638","authenticated-orcid":false,"given":"Mei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9293-7368","authenticated-orcid":false,"given":"Mei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5415-5943","authenticated-orcid":false,"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9083-9233","authenticated-orcid":false,"given":"Xinwen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2281-9834","authenticated-orcid":false,"given":"Fen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5216-0356","authenticated-orcid":false,"given":"Haiyin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)30866-8"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)60052-4"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200601-004TK"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007713"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000365051"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00141010"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2011.565049"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0322oc"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00212.2010"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.829673"},{"key":"e_1_2_14_11_2","first-page":"150","article-title":"Chinese 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