{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:03:15Z","timestamp":1773000195999,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":327,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the mediating role of body mass index (BMI) in the association between obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, 445 adult patients diagnosed with OSA at Zigong Fourth People\u2019s Hospital (2022\u20132024) were initially enrolled. After applying inclusion\/exclusion criteria, 309 participants were included. Demographic characteristics and clinical parameters were collected. Correlation analysis and structural equation modeling (SEM) were utilized to assess BMI\u2019s mediation effect between OSA and NAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Correlation analyses revealed significant positive associations of BMI with both OSA (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.296,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and NAFLD (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.225,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), while OSA and NAFLD were directly correlated (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.199,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Mediation analysis demonstrated a significant indirect effect of OSA on NAFLD through BMI (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.044, 95% CI: 0.004\u20130.084), accounting for 22.5% of the total effect. These findings remained robust after adjusting for covariates including sex, age, smoking status, hypertension, and diabetes mellitus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BMI serves as a critical mediator in the OSA\u2013NAFLD relationship, suggesting that integrated weight management strategies should be incorporated into OSA therapy to reduce hepatic risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/carj\/8606659","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T09:37:12Z","timestamp":1763977032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediating Role of BMI in the Association Between Obstructive Sleep Apnea and Nonalcoholic Fatty Liver Disease: A Cross\u2010Sectional Mediation 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