{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:03:41Z","timestamp":1770966221078,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background<\/jats:title>\n \n Cystic fibrosis (CF) is one of the most common autosomal recessive diseases in the world population. Allergic bronchopulmonary aspergillosis (ABPA) is a severe complication of CF, the diagnosis of which is based on symptoms and blood IgE levels. However, many techniques of specific IgG levels\u2019 measures are used, whose clinical significance is still unclear. We evaluated the clinical evolution of CF in children who presented a first\n A. fumigatus<\/jats:italic>\n IgG seroconversion.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Monocentric pediatric case\u2010control study led in Rouen, France. Every patient with a first\n A. fumigatus<\/jats:italic>\n IgG seroconversion was paired with a seronegative patient. Clinical data, functional respiratory investigations, CT scan, and biologic data were collected a year before (\n Y<\/jats:italic>\n \u22121<\/jats:sub>\n ), at the time of IgG seroconversion (\n Y<\/jats:italic>\n 0<\/jats:sub>\n ), and one year after (\n Y<\/jats:italic>\n +1<\/jats:sub>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty\u2010six cases were paired with 36 controls. Median age was 8. Forced expiratory volume in 1\u2009s (FEV1) and forced vital capacity (FVC) were significantly lower at\n Y<\/jats:italic>\n +1<\/jats:sub>\n (\n p<\/jats:italic>\n = 0.025) and\n Y<\/jats:italic>\n 0<\/jats:sub>\n (\n p<\/jats:italic>\n = 0.027), respectively, and more pulmonary exacerbations were observed in the case population (\n p<\/jats:italic>\n = 0.047). Higher levels of specific IgE against\n A. fumigatus<\/jats:italic>\n were observed at\n Y<\/jats:italic>\n \u22121<\/jats:sub>\n (\n p<\/jats:italic>\n = 0.001),\n Y<\/jats:italic>\n 0<\/jats:sub>\n (\n p<\/jats:italic>\n = 0.014), and\n Y<\/jats:italic>\n +1<\/jats:sub>\n (\n p<\/jats:italic>\n = 0.04) in the case population. On the CT scan, bronchiectasis and pulmonary infiltrates were more frequent in the case population (\n p<\/jats:italic>\n = 0.01 and\n p<\/jats:italic>\n = 0.003, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n We found that the first\n A. fumigatus<\/jats:italic>\n IgG seroconversion was associated with changes in clinical, respiratory functional, biologic, and radiologic parameters in CF pediatric population.\n A. fumigatus<\/jats:italic>\n IgG seroconversion is an important step in the evolution of CF. A systematic search for seroconversion is therefore essential to assess the measures to be taken.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1155\/carj\/9033903","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:04:11Z","timestamp":1770962651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["How Should IgG Seroconversion to\n Aspergillus fumigatus<\/i>\n be Interpreted in Children With Cystic Fibrosis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-871X","authenticated-orcid":false,"given":"Hortense","family":"Petat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Lubrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Couderc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-1184","authenticated-orcid":false,"given":"Christophe","family":"Marguet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00061-2024"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12595"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.016003464.x"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-423oc"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.3.639"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0917"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2009.01.001"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/mcp.0000000000000106"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02620-3"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/mcp.0b013e32833e24a6"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206750"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01068-2015"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0087oc"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000231"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.007"}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carj\/9033903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carj\/9033903","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carj\/9033903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:04:12Z","timestamp":1770962652000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carj\/9033903"}},"subtitle":[],"editor":[{"given":"Halime Nayir","family":"B\u00fcy\u00fck\u015fahin","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/carj\/9033903"],"URL":"https:\/\/doi.org\/10.1155\/carj\/9033903","archive":["Portico"],"relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"value":"1198-2241","type":"print"},{"value":"1916-7245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9033903"}}