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The patient, following the prescription from her private dentist, presented to the dental emergency unit, referring to the onset of an increasing swelling of the upper lip a few hours after the application of chlorhexidine gel. After the exclusion of a possible infective process starting from the maxillary incisors, the patient was prescribed prednisone and exhibited a quick remission of the swelling. This report aims to emphasize the importance of a correct differential diagnosis to warrant an optimal therapeutic approach to the patient, since swellings of the upper lip could be related to different conditions.<\/jats:p>","DOI":"10.1155\/carm\/2841092","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:51:49Z","timestamp":1776055909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Topical Chlorhexidine\u2010Induced Oral Allergic Reaction: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0200-3895","authenticated-orcid":false,"given":"Matteo","family":"Zotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-9439","authenticated-orcid":false,"given":"Katia","family":"Rupel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4152-3437","authenticated-orcid":false,"given":"Marina","family":"Diolos\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3427-0514","authenticated-orcid":false,"given":"Giulia","family":"Ottaviani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2023.02.001"},{"key":"e_1_2_8_2_2","first-page":"83","article-title":"Chlorhexidine Gel Used as Antiseptic in Periodontal Pockets","volume":"33","author":"Mummolo S.","year":"2019","journal-title":"Journal of Biological Regulators & Homeostatic Agents"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05643-0"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2018.10.004"},{"key":"e_1_2_8_5_2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.adaj.2017.01.021","article-title":"Chlorhexidine Mouthwash as an Adjunct to Mechanical Therapy in Chronic Periodontitis: A Meta-Analysis","volume":"148","author":"Costa L. 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