{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:51:50Z","timestamp":1781869910997,"version":"3.54.5"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":169,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) most commonly arises in nodal regions but may also present extranodally. We report two cases of large B\u2010cell lymphoma developing in postpneumonectomy cavities more than a decade after surgery for primary lung carcinoma. In both patients, no history of systemic immunodeficiency, organ transplantation, or chronic immunosuppressive therapy was present, and HIV, hepatitis B, and hepatitis C serologies were negative. In Case 1, the lymphoma showed an activated postgerminal center phenotype and was negative for EBER and HHV\u20108. In Case 2, the tumor was CD20\u2010negative and EBER\u2010positive, with pathological features of inflammation\u2010associated large B\u2010cell lymphoma. PET\u2010CT was used for staging and response assessment in both patients, and both achieved complete metabolic remission after curative\u2010intent chemotherapy. These cases underscore a rare clinical entity that differs pathophysiologically from pyothorax\u2010associated lymphoma (PAL) or primary effusion lymphoma (PEL). They highlight the postpneumonectomy cavity as a rare but potentially permissive microenvironment for large B\u2010cell lymphomagenesis and underscore the biological heterogeneity of these presentations.<\/jats:p>","DOI":"10.1155\/carm\/2936999","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:05:38Z","timestamp":1781867138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse Large B\u2010Cell Lymphoma Arising in Postpneumonectomy Cavities: Report of Two Cases and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6803-8228","authenticated-orcid":false,"given":"Patricia","family":"Capdevila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobal","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Escriv\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Soria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Esteve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Gomez-Codina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_12_1_2","first-page":"1200","article-title":"The 2022 WHO Classification of Lymphoid Neoplasms","volume":"140","author":"Campo E.","year":"2022","journal-title":"Blood"},{"key":"e_1_2_12_2_2","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1200\/JCO.2002.09.021","article-title":"Pyothorax-Associated Lymphoma: A Review of 106 Cases","volume":"20","author":"Aozasa K.","year":"2002","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s167392"},{"key":"e_1_2_12_4_2","article-title":"Fluid Overload-Associated Large B-Cell Lymphoma: A Distinct Clinical Entity","volume":"15","author":"Kaji D.","year":"2023","journal-title":"Cancers (Basel)"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.09.002"},{"key":"e_1_2_12_6_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1440-1827.2008.02288.x","article-title":"Epstein-Barr Virus-Associated Post-Surgical Diffuse Large B-Cell Lymphoma Arising Adjacent to a Prosthetic Material","volume":"58","author":"Fujimoto K.","year":"2008","journal-title":"Pathology International"},{"key":"e_1_2_12_7_2","first-page":"190","article-title":"Chest Wall Diffuse Large B-cell Lymphoma Appearing 20 Years After Trauma: A Case Report","volume":"3","author":"Atoini F.","year":"2012","journal-title":"Thoracic Cancer"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/2936999","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carm\/2936999","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/2936999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:05:40Z","timestamp":1781867140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carm\/2936999"}},"subtitle":[],"editor":[{"given":"Sreeja","family":"Dattachoudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/carm\/2936999"],"URL":"https:\/\/doi.org\/10.1155\/carm\/2936999","archive":["Portico"],"relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2936999"}}