{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T08:02:08Z","timestamp":1779868928267,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":146,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Semaglutide, a glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonist, is widely used for weight management and glycemic control. While its metabolic and gastrointestinal effects are well characterized, its potential influence on pituitary function remains underexplored. To our knowledge, this appears to be among the first published reports of transient hyperprolactinemia associated with semaglutide use in a middle\u2010aged woman with well\u2010controlled Hashimoto\u2019s thyroiditis. The patient developed prolactin levels approaching 100\u2009ng\/mL without clinical symptoms or MRI evidence of pituitary adenoma. Prolactin normalized after semaglutide discontinuation, without any pharmacologic intervention. This case raises the hypothesis that GLP\u20101 receptor agonism may influence prolactin regulation in susceptible individuals, potentially through central neuroendocrine pathways involving prolactin\u2010releasing peptide (PrRP) signaling or dopaminergic modulation. Clinicians should consider medication\u2010related hyperprolactinemia in the differential diagnosis when elevated prolactin is detected during GLP\u20101 receptor agonist therapy.<\/jats:p>","DOI":"10.1155\/carm\/3016596","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T07:04:08Z","timestamp":1779865448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transient Hyperprolactinemia Associated With Semaglutide in a Patient With Hashimoto\u2019s Thyroiditis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0903-0608","authenticated-orcid":false,"given":"Gabriela N. 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